DDX17

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DDX17
Identifiers
Aliases DDX17, P72, RH70, DEAD-box helicase 17
External IDs MGI: 1914290 HomoloGene: 101101 GeneCards: DDX17
RNA expression pattern
PBB GE DDX17 208151 x at fs.png

PBB GE DDX17 208718 at fs.png

PBB GE DDX17 208719 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030881
NM_001098504
NM_001098505
NM_006386

NM_001040187
NM_152806
NM_199079
NM_199080

RefSeq (protein)

NP_001091974
NP_006377

Location (UCSC) Chr 22: 38.48 – 38.51 Mb Chr 15: 79.53 – 79.55 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Probable ATP-dependent RNA helicase DDX17 (p72) is an enzyme that in humans is encoded by the DDX17 gene.[3][4]

Function[edit]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species but not by dsDNA. This protein and that encoded by DDX5 gene are more closely related to each other than to any other member of the DEAD box family. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms with the longer transcript reported to also initiate translation at a non-AUG (CUG) start site.[4]

Interactions[edit]

DDX17 has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lamm GM, Nicol SM, Fuller-Pace FV, Lamond AI (Dec 1996). "p72: a human nuclear DEAD box protein highly related to p68". Nucleic Acids Res. 24 (19): 3739–47. doi:10.1093/nar/24.19.3739. PMC 146168Freely accessible. PMID 8871553. 
  4. ^ a b "Entrez Gene: DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17". 
  5. ^ Ogilvie VC, Wilson BJ, Nicol SM, Morrice NA, Saunders LR, Barber GN, Fuller-Pace FV. "The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells". Nucleic Acids Res. 31 (5): 1470–80. doi:10.1093/nar/gkg236. PMC 149829Freely accessible. PMID 12595555. 
  6. ^ Wilson BJ, Giguère V (Nov 2007). "Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis". BMC Genomics. 8: 419. doi:10.1186/1471-2164-8-419. PMC 3225811Freely accessible. PMID 18005418. 
  7. ^ Wilson BJ, Bates GJ, Nicol SM, Gregory DJ, Perkins ND, Fuller-Pace FV (Aug 2004). "The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner". BMC Mol. Biol. 5: 11. doi:10.1186/1471-2199-5-11. PMC 514542Freely accessible. PMID 15298701. 

Further reading[edit]