DEFB105A

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DEFB105A
Identifiers
Aliases DEFB105A, BD-5, DEFB-5, DEFB105, defensin beta 105A
External IDs MGI: 1924924 HomoloGene: 17531 GeneCards: DEFB105A
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_152250

NM_152802

RefSeq (protein)

NP_689463
NP_001035793

NP_690015.1
NP_690015

Location (UCSC) Chr 8: 7.82 – 7.82 Mb Chr 8: 19.11 – 19.11 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Beta-defensin 105 is a protein that in humans is encoded by the DEFB105A gene.[3][4][5]

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105A, represents the more centromeric copy.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. doi:10.1073/pnas.042692699. PMC 122330Freely accessible. PMID 11854508. 
  4. ^ Semple CA, Rolfe M, Dorin JR (May 2003). "Duplication and selection in the evolution of primate beta-defensin genes". Genome Biol. 4 (5): R31. doi:10.1186/gb-2003-4-5-r31. PMC 156587Freely accessible. PMID 12734011. 
  5. ^ a b "Entrez Gene: DEFB105A defensin, beta 105A". 

Further reading[edit]