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DEFB105A

From Wikipedia, the free encyclopedia
DEFB105A
Identifiers
AliasesDEFB105A, BD-5, DEFB-5, DEFB105, defensin beta 105A
External IDsMGI: 1924924; HomoloGene: 17531; GeneCards: DEFB105A; OMA:DEFB105A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_152250

NM_152802

RefSeq (protein)

NP_689463

NP_690015

Location (UCSC)Chr 8: 7.82 – 7.82 MbChr 8: 19.16 – 19.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Beta-defensin 105 is a protein that is encoded by the DEFB105A gene in humans.[5][6][7]

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: Alpha defensins, Beta defensins and Theta defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105A, represents the more centromeric copy.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186562Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043787Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. Bibcode:2002PNAS...99.2129S. doi:10.1073/pnas.042692699. PMC 122330. PMID 11854508.
  6. ^ Semple CA, Rolfe M, Dorin JR (May 2003). "Duplication and selection in the evolution of primate beta-defensin genes". Genome Biol. 4 (5): R31. doi:10.1186/gb-2003-4-5-r31. PMC 156587. PMID 12734011.
  7. ^ a b "Entrez Gene: DEFB105A defensin, beta 105A".

Further reading

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