DGKB

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DGKB
Identifiers
Aliases DGKB, DAGK2, DGK, DGK-BETA, diacylglycerol kinase beta
External IDs MGI: 2442474 HomoloGene: 37875 GeneCards: DGKB
Genetically Related Diseases
type 2 diabetes mellitus, lymphoblastic leukemia[1]
RNA expression pattern
PBB GE DGKB 216307 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004080
NM_145695

NM_178681

RefSeq (protein)

NP_004071
NP_663733

NP_848796.2
NP_848796

Location (UCSC) Chr 7: 14.15 – 14.97 Mb Chr 12: 37.88 – 38.63 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Diacylglycerol kinase beta is an enzyme that in humans is encoded by the DGKB gene.[4][5]

Function[edit]

Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene.[5]

References[edit]

Further reading[edit]

  • Caricasole A, Bettini E, Sala C, Roncarati R, Kobayashi N, Caldara F, Goto K, Terstappen GC (February 2002). "Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties". The Journal of Biological Chemistry. 277 (7): 4790–6. doi:10.1074/jbc.M110249200. PMID 11719522. 
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.