DHPS

DHPS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DHS, 1RLZ, 1ROZ, 1RQD
Identifiers
Aliases	DHPS, deoxyhypusine synthase, DHS, DS, MIG13, NEDSSWI
External IDs	OMIM: 600944; MGI: 2683592; HomoloGene: 1453; GeneCards: DHPS; OMA:DHPS - orthologs
EC number	2.5.1.46
Gene location (Human)
Chr.	Chromosome 19 (human)
End	12,681,880 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,801,791 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; ganglionic eminence; ; primary visual cortex; ; pituitary gland; ; anterior pituitary; ; right uterine tube; ; left ovary; ; prostate; ; muscle of thigh; ; prefrontal cortex;
	Top expressed in
	embryo; ; embryo; ; superior frontal gyrus; ; neural layer of retina; ; aortic valve; ; muscle of thigh; ; ascending aorta; ; supraoptic nucleus; ; epiblast; ; morula;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein binding; identical protein binding; deoxyhypusine synthase activity;
Cellular component	cytosol; cytoplasm;
Biological process	protein homotetramerization; protein biosynthesis; positive regulation of T cell proliferation; glucose homeostasis; positive regulation of cell population proliferation; spermidine metabolic process; spermidine catabolic process; peptidyl-lysine modification to peptidyl-hypusine;
	Sources:Amigo / QuickGO
Orthologs
	1725
	330817
	ENSG00000095059
	ENSMUSG00000060038
	P49366
	Q3TXU5
NM_001206974; NM_001930; NM_013406; NM_001369691; NM_001369692;
	NM_001369693
	NM_001039514; NM_201408
NP_001193903; NP_001921; NP_037538; NP_001356620; NP_001356621;
	NP_001356622
	NP_001034603
	Wikidata
View/Edit Human	View/Edit Mouse

Deoxyhypusine synthase is an enzyme that in humans is encoded by the DHPS gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000095059 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060038 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Joe YA, Wolff EC, Park MH (Oct 1995). "Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins". J Biol Chem. 270 (38): 22386–92. doi:10.1074/jbc.270.38.22386. PMID 7673224.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: DHPS deoxyhypusine synthase".

References

Further reading