DHPS

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This article is about the gene coding for the enzyme deoxyhypusine synthase. For another enzyme commonly abbreviated DHPS, see Dihydropteroate synthetase. For other uses, see DHPS (disambiguation).
DHPS
Protein DHPS PDB 1dhs.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DHPS, deoxyhypusine synthase, DHS, DS, MIG13
External IDs MGI: 2683592 HomoloGene: 1453 GeneCards: 1725
EC number 2.5.1.46
RNA expression pattern
PBB GE DHPS 202802 at tn.png

PBB GE DHPS 207831 x at tn.png

PBB GE DHPS 211558 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001206974
NM_001930
NM_013406
NM_013407

NM_001039514
NM_201408

RefSeq (protein)

NP_001193903.1
NP_001921.1
NP_037538.1

NP_001034603.1

Location (UCSC) Chr 19: 12.68 – 12.68 Mb Chr 8: 85.07 – 85.08 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Deoxyhypusine synthase is an enzyme that in humans is encoded by the DHPS gene.[3][4]

The unusual amino acid hypusine is formed posttranslationally and is only found in a single cellular protein, eukaryotic translation initiation factor 5A. In the first step of hypusine biosynthesis, deoxyhypusine synthase catalyzes the NAD-dependent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the EIF5A precursor protein to form the intermediate deoxyhypusine residue. This gene consists of nine exons spanning 6.6 kb. Three transcript variants have been isolated. However, only transcript variant 1 encodes an active protein. The shorter variants may act as modulating factors of DHPS activity.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Joe YA, Wolff EC, Park MH (Oct 1995). "Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins". J Biol Chem. 270 (38): 22386–92. doi:10.1074/jbc.270.38.22386. PMID 7673224. 
  4. ^ a b "Entrez Gene: DHPS deoxyhypusine synthase". 

Further reading[edit]