Docking protein 5 is a protein that in humans is encoded by the DOK5gene.[5][6]
Function
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP.[6]
^Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID15286081.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Further reading
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID11780052.
Shi N, Zhou W, Tang K, et al. (2003). "Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of human dok-5 protein". Acta Crystallogr. D. 58 (Pt 12): 2170–2. doi:10.1107/S090744490201644X. PMID12454490.
Favre C, Gérard A, Clauzier E, et al. (2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells". Genes Immun. 4 (1): 40–5. doi:10.1038/sj.gene.6363891. PMID12595900.
Cai D, Dhe-Paganon S, Melendez PA, et al. (2003). "Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5". J. Biol. Chem. 278 (28): 25323–30. doi:10.1074/jbc.M212430200. PMID12730241.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Crowder RJ, Enomoto H, Yang M, et al. (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID15286081.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
Shi L, Yue J, You Y, et al. (2007). "Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation". Cell. Signal. 18 (11): 1995–2003. doi:10.1016/j.cellsig.2006.03.007. PMID16647839.