DPP6

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DPP6
Protein DPP6 PDB 1xfd.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DPP6, DPPX, VF2, MRD33, DPL1, dipeptidyl peptidase like 6
External IDs MGI: 94921 HomoloGene: 22560 GeneCards: DPP6
Genetically Related Diseases
colorectal cancer, post-traumatic stress disorder, pancreatic cancer, amyotrophic lateral sclerosis[1]
RNA expression pattern
PBB GE DPP6 gnf1h05777 s at fs.png

PBB GE DPP6 207789 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001039350
NM_001290252
NM_001290253
NM_001936
NM_130797

NM_001136060
NM_001198886
NM_010075
NM_207282

RefSeq (protein)
Location (UCSC) Chr 7: 153.89 – 154.89 Mb Chr 5: 26.82 – 27.73 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Dipeptidyl aminopeptidase-like protein 6 is a protein that in humans is encoded by the DPP6 gene.[4][5]

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5]

References[edit]

Further reading[edit]