DSP-4

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DSP-4
DSP-4.svg
Names
IUPAC name
N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine
Identifiers
3D model (JSmol)
ChemSpider
Properties
C11H15BrClN
Molar mass 276.60 g/mol
Density 1.339 g/cm3
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

DSP-4, or N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine, is a neurotoxin selective for noradrenergic neurons, capable of crossing the blood–brain barrier.[1]

It exerts transient effects in peripheral sympathetic neurons, but more permanent changes within neurons of the central nervous system. It can induce long-term depletion in cortical and spinal levels of noradrenaline.[2]

See also[edit]

References[edit]

  1. ^ Daw NW, Videen TO, Parkinson D, Rader RK (1985). "DSP-4 (N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine) Depletes Noradrenaline in Kitten Visual Cortex Without Altering the Effects of Monocular Deprivation". J. Neurosci. 5 (7): 1925–1933. PMID 3926960. 
  2. ^ Jaim-Etcheverry G, Mari'a Zieher L (1980). "DSP-4: A novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats". Brain Res. 188 (2): 513–523. doi:10.1016/0006-8993(80)90049-9. PMID 7370771.