DYNC1I1

DYNC1I1
Identifiers
Aliases	DYNC1I1, dynein, cytoplasmic 1, intermediate chain 1, DNCI1, DNCIC1, dynein cytoplasmic 1 intermediate chain 1
External IDs	OMIM: 603772; MGI: 107743; HomoloGene: 68398; GeneCards: DYNC1I1; OMA:DYNC1I1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	96,110,322 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	6,028,039 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; pons; ; pars compacta; ; middle temporal gyrus; ; frontal pole; ; superior vestibular nucleus; ; cerebellar vermis; ; pars reticulata; ; Brodmann area 23; ; lateral nuclear group of thalamus;
	Top expressed in
	pontine nuclei; ; ventral tegmental area; ; medulla oblongata; ; medial vestibular nucleus; ; dorsal tegmental nucleus; ; perirhinal cortex; ; deep cerebellar nuclei; ; lobe of cerebellum; ; barrel cortex; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule motor activity; spectrin binding; microtubule binding; protein binding; cytoskeletal motor activity; plus-end-directed microtubule motor activity; dynein light chain binding; dynein heavy chain binding;
Cellular component	cytoplasm; recycling endosome; vesicle; cytosol; spindle pole; chromosome; perinuclear region of cytoplasm; dynein complex; cytoplasmic ribonucleoprotein granule; microtubule; chromosome, centromeric region; cytoskeleton; nucleus; kinetochore; cytoplasmic dynein complex;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II; vesicle transport along microtubule; endoplasmic reticulum to Golgi vesicle-mediated transport; microtubule-based movement;
	Sources:Amigo / QuickGO
Orthologs
	1780
	13426
	ENSG00000158560
	ENSMUSG00000029757
	O14576
	O88485
	NM_001135556; NM_001135557; NM_001278421; NM_001278422; NM_004411
	NM_001191023; NM_001191025; NM_001191026; NM_001191027; NM_010063
	NP_001129028; NP_001129029; NP_001265350; NP_001265351; NP_004402
	NP_001177952; NP_001177954; NP_001177955; NP_001177956; NP_034193
	Wikidata
View/Edit Human	View/Edit Mouse

Cytoplasmic dynein 1 intermediate chain 1 is a protein that in humans is encoded by the DYNC1I1 gene.^[5]^[6]^[7]

In melanocytic cells DYNC1I1 gene expression may be regulated by MITF.^[8]

Template:PBB Summary

Interactions

DYNC1I1 has been shown to interact with DYNLL1.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158560 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029757 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Crackower MA, Sinasac DS, Xia J, Motoyama J, Prochazka M, Rommens JM, Scherer SW, Tsui LC (May 1999). "Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human". Genomics. 55 (3): 257–67. doi:10.1006/geno.1998.5665. PMID 10049579.
^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
^ "Entrez Gene: DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1".
^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
^ Diefenbach, Russell J; Diefenbach Eve; Douglas Mark W; Cunningham Anthony L (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry. 41 (50). United States: 14906–15. doi:10.1021/bi026417u. ISSN 0006-2960. PMID 12475239. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)

Interactions

References

Further reading