DYRK2

DYRK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3K2L, 3KVW, 4AZF
Identifiers
Aliases	DYRK2, dual specificity tyrosine phosphorylation regulated kinase 2
External IDs	OMIM: 603496; MGI: 1330301; HomoloGene: 48437; GeneCards: DYRK2; OMA:DYRK2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	67,665,406 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	118,706,114 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of sigmoid colon; ; Skeletal muscle tissue of rectus abdominis; ; vastus lateralis muscle; ; pylorus; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; visceral pleura; ; right ventricle; ; hair follicle;
	Top expressed in
	otolith organ; ; utricle; ; epithelium of lens; ; hand; ; knee joint; ; retinal pigment epithelium; ; left colon; ; hair follicle; ; digastric muscle; ; sternocleidomastoid muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; manganese ion binding; kinase activity; protein binding; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; magnesium ion binding; protein serine/threonine kinase activity;
Cellular component	cytoplasm; ubiquitin ligase complex; nucleus; nucleoplasm; cytosol; ribonucleoprotein complex;
Biological process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of glycogen biosynthetic process; phosphorylation; cellular response to DNA damage stimulus; protein phosphorylation; smoothened signaling pathway; apoptotic process; regulation of signal transduction by p53 class mediator; peptidyl-tyrosine phosphorylation; negative regulation of calcineurin-NFAT signaling cascade;
	Sources:Amigo / QuickGO
Orthologs
	8445
	69181
	ENSG00000127334
	ENSMUSG00000028630
	Q92630
	Q5U4C9
	NM_006482; NM_003583
	NM_001014390
	NP_003574; NP_006473
	NP_001014412
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity tyrosine-phosphorylation-regulated kinase 2 is an enzyme that in humans is encoded by the DYRK2 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127334 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028630 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Becker W, Weber Y, Wetzel K, Eirmbter K, Tejedor FJ, Joost HG (Nov 1998). "Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases". J Biol Chem. 273 (40): 25893–902. doi:10.1074/jbc.273.40.25893. PMID 9748265.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2".

References

Further reading