The park has several overlooks, a visitor center, a 21-site campground and a group campsite, one picnic area, and a 9-mile (14 km) loop hiking trail with two cutovers to allow shorter trips. Safety concerns include the relative isolation of the park (gas, food and medical care are over 30 miles (48 km) away in Moab), lightning danger and unfenced cliffs. Nearby Moab is a noted center for mountain biking. Bikes in the park are allowed on paved roads, and there is a mountain bike trail called Intrepid Trail near the State Park Visitor's Center with loops of varying levels of difficulty. Hunting is not allowed in the park.
The park is so named because of its use as a natural corral by cowboys in the 19th century, where horses often died of exposure. Dead Horse Point has frequently been noted on lists of unusual place names.
The area was also used in the final 'Grand Canyon' scene of the 1991 film Thelma & Louise.