Dermatopontin

DPT
Identifiers
Aliases	DPT, TRAMP, dermatopontin
External IDs	OMIM: 125597; MGI: 1928392; HomoloGene: 1458; GeneCards: DPT; OMA:DPT - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	168,729,206 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	164,651,835 bp
RNA expression pattern
	Top expressed in
	smooth muscle tissue; ; muscle layer of sigmoid colon; ; epithelium of colon; ; right auricle; ; subcutaneous adipose tissue; ; lactiferous gland; ; left uterine tube; ; gallbladder; ; gastric mucosa; ; fundus;
	Top expressed in
	semi-lunar valve; ; aortic valve; ; cervix; ; subcutaneous adipose tissue; ; intercostal muscle; ; skin of abdomen; ; carotid body; ; ankle; ; ascending aorta; ; white adipose tissue;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	extracellular matrix structural constituent; protein binding;
Cellular component	extracellular matrix; extracellular region; extracellular exosome; extracellular space; collagen-containing extracellular matrix;
Biological process	cell adhesion; negative regulation of cell population proliferation; collagen fibril organization;
	Sources:Amigo / QuickGO
Orthologs
	1805
	56429
	ENSG00000143196
	ENSMUSG00000026574
	Q07507
	Q9QZZ6
	NM_001937
	NM_019759
	NP_001928
	NP_062733
	Wikidata
View/Edit Human	View/Edit Mouse

Dermatopontin is a protein that in humans is encoded by the DPT gene.^[5]^[6]

Function

Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF beta through interaction with decorin.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143196 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026574 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Superti-Furga A, Rocchi M, Schafer BW, Gitzelmann R (Oct 1993). "Complementary DNA sequence and chromosomal mapping of a human proteoglycan-binding cell-adhesion protein (dermatopontin)". Genomics. 17 (2): 463–7. doi:10.1006/geno.1993.1348. PMID 8104875.
^ ^a ^b "Entrez Gene: DPT dermatopontin".

Function

References

Further reading