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Dhevalapally B. Ramachary

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Dhevalapally B. Ramachary
Born
Thatikal, Nalgonda, India
NationalityIndian
Alma materUniversity of Hyderabad
Indian Institute of Science
The Scripps Research Institute
Known forOrganic Chemistry, Organocatalysis, Supramolecular-organocatalysis, Asymmetric Catalysis, Click chemistry
Awards♦ Fellow, National Academy of Sciences, Allahabad (2021)
♦ Fellow, Royal society of Chemistry, London (2020)
♦ Fellow, Indian Academy of Sciences, Bangalore (2019)
♦ Fellow, Telangana Academy of Sciences, Hyderabad (2016)
Scientific career
FieldsChemistry
InstitutionsUniversity of Hyderabad
Thesis Total synthesis of Sesquiterpenes containing three contiguous quarternary carbon atoms  (2001)
Doctoral advisorProf. Adusumilli Srikrishna

Dhevalapally B. Ramachary FTAS, FRSC, FASc, FNASc, also known as D. B. Ramachary (born 1973), is an Indian chemist and professor at the School of Chemistry, University of Hyderabad. He has made numerous contributions in various fields of chemical science.

Early life and education

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D. B. Ramachary was born to Shri Ramalingaiahchary and Ramalingamma in 1973, at Thatikal village, Nakrekal mandal, Nalgonda district of Telangana. He did his early schooling at ZPHS schools at Thatikal and Nakrekal, and later joined for an under graduate BSc programme at Nagarjuna Government College (Autonomous) at Nalgonda (1991–1994). Later, he moved to School of Chemistry, University of Hyderabad for pursuing MSc chemistry (1994–96), and then he obtained a PhD in synthetic organic chemistry under the guidance of Prof. A. Srikrishna at Indian Institute of Science in 1996–2001 for the total synthesis of sesquiterpenes.[1][2]

Soon after his PhD in 2001, he moved to US as a Skaggs Postdoctoral Fellow and worked with Carlos F. Barbas III at Department of Chemistry and Molecular Biology, The Scripps Research Institute in La Jolla, United States during 2002–2005 for the development of small molecular-catalysis.[3][4][5][6][7]

Academic career

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Ramachary was lecturer (2005–2007), reader (2007–2010), associate professor (2010–2013), and at present he is a full professor of organic chemistry since 2013 at the Catalysis laboratory, School of Chemistry, University of Hyderabad. He has authored more than 100 research papers.[8]

Research

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In 2005, when Ramachary started his own research career at School of Chemistry, UoH, he showed interest towards discovering green reactions and catalysts. His laboratory mainly focused on the development of organocatalytic sequential one-pot reactions, asymmetric supramolecular catalysis and organocatalysis, development of multi-component and multi-catalysis cascade reactions,[9] and metal-free carbonyls based click chemistry.[10][11][12]

His laboratory discovered important reactions based on three-component reductive alkylation (TCRA)[13][14][15][16] and push-pull dienamine (PPD) reactions.[17][18][19][20] His research also focuses on the theoretical aspects of organocatalysis in finding out the suitable organocatalyst for stereoselective reactions using computational resources which helps in achieving better synthetic methodologies. Using this, his research group observed the electrostatic and dipole-dipole interactions in proline-catalyzed asymmetric desymmetrization of pro-chiral ketones with nitrosobenzene.[21] He has also examined the trapping or stabilizing of king size pre- or post-transition states of asymmetric reactions by designing new tool ‘asymmetric supramolecular catalysis’ through which characterization of large-size supramolecular rings in the pre-transition state (pre-TS) of enol- or enamine-based Michael reactions for high asymmetric induction was reported.[22][23] His contributions through original developed reactions were used by organic, medicinal, material chemists and these reactions became well-known organic reactions to be named after him. The reactions which are named after him are: 1) Ramachary Reductive Coupling Reaction,[24] 2) Ramachary-Bressy-Wang Cycloaddition,[25] 3) Ramachary Aminoenyne-catalysis,[26][27][28][29] 4) Ramachary Base Induced Ring Opening (BIRO) Reaction,[30][31] 5) Ramachary Azide-Carbonyl [3+2]-Cycloaddition.[32][33][34]

Awards and honors

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References

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  1. ^ Srikrishna, A.; Ramachary, D. B. (3 September 1999). "First total synthesis of (±)-β-microbiotene, (±)-microbiotol and (±)-cyclocuparenol". Tetrahedron Letters. 40 (36): 6669–6670. doi:10.1016/S0040-4039(99)01342-8. ISSN 0040-4039.
  2. ^ Srikrishna, A.; Ramachary, D. B. (2007). "Total Synthesis of (±)-β-Microbiotene (I), (±)-Microbiotol (II), (±)-Cyclocuparanol (III) and (±)-β-Cuparenones (IV)". ChemInform. 38 (38). doi:10.1002/chin.200738174.
  3. ^ Ramachary, D. B.; Barbas, Carlos F. (17 March 2005). "Direct Amino Acid-Catalyzed Asymmetric Desymmetrization of meso-Compounds: Tandem Aminoxylation/O−N Bond Heterolysis Reactions". Organic Letters. 7 (8): 1557–1580. doi:10.1021/ol050246e. PMID 15816756.
  4. ^ Suri, Jeff T.; Ramachary, D. B.; Barbas, Carlos F. (1 March 2005). "Mimicking Dihydroxy Acetone Phosphate-Utilizing Aldolases through Organocatalysis: A Facile Route to Carbohydrates and Aminosugars". Organic Letters. 7 (7): 1383–1385. doi:10.1021/ol0502533. PMID 15787512.
  5. ^ Ramachary, D. B.; Anebouselvy, K.; Chowdari, Naidu S.; Barbas, Carlos F. (6 August 2004). "Direct Organocatalytic Asymmetric Heterodomino Reactions: The Knoevenagel/Diels−Alder/Epimerization Sequence for the Highly Diastereoselective Synthesis of Symmetrical and Nonsymmetrical Synthons of Benzoannelated Centropolyquinanes". The Journal of Organic Chemistry. 69 (18): 5838–5849. doi:10.1021/jo049581r. PMID 15373469.
  6. ^ Ramachary, D. B.; Chowdari, Naidu S.; Barbas, Carlos F. (15 September 2003). "Organocatalytic Asymmetric Domino Knoevenagel/Diels–Alder Reactions: A Bioorganic Approach to the Diastereospecific and Enantioselective Construction of Highly Substituted Spiro[5,5]undecane-1,5,9-triones". Angewandte Chemie. 115 (35): 4365–4369. Bibcode:2003AngCh.115.4365R. doi:10.1002/ange.200351916.
  7. ^ Chowdari, Naidu S.; Ramachary, D. B.; Barbas, Carlos F. (22 April 2003). "Organocatalytic Asymmetric Assembly Reactions: One-Pot Synthesis of Functionalized β-Amino Alcohols from Aldehydes, Ketones, and Azodicarboxylates". Organic Letters. 5 (10): 1685–1688. doi:10.1021/ol034333n. PMID 12735752.
  8. ^ Prof. D. B. Ramachary Research Laboratory Homepage, http://chemistry.uohyd.ac.in/~dbr/index.htm
  9. ^ Ramachary, D. B.; Sangeeta Jain (1 December 2010). "Sequential one-pot combination of multi-component and multi-catalysis cascade reactions: an emerging technology in organic synthesis". Organic & Biomolecular Chemistry. 9 (5): 1277–1300. doi:10.1039/C0OB00611D. PMID 21120241.
  10. ^ Ramachary, D. B.; Kishor, Mamillapalli; Vijayendar Reddy, Y. (6 February 2008). "Development of Pharmaceutical Drugs, Drug Intermediates and Ingredients by Using Direct Organo-Click Reactions". European Journal of Organic Chemistry. 2008 (6): 975–993. doi:10.1002/ejoc.200701014.
  11. ^ Ramachary, D. B.; Rumpa Mondal; Venkaiah, Chintalapudi (28 May 2010). "Rapid Synthesis of Functionalized Indenes, Triazoles, and Glucocorticoid Receptor Modulators by Sequential Multicatalysis Cascade Reactions". European Journal of Organic Chemistry. 2010 (17): 3205–3210. doi:10.1002/ejoc.201000220.
  12. ^ Ramachary, D. B.; Shaahank, Adluri B.; Karthik, S. (30 July 2014). "An Organocatalytic Azide–Aldehyde [3+2] Cycloaddition: High-Yielding Regioselective Synthesis of 1,4-Disubstituted 1,2,3-Triazoles". Angewandte Chemie International Edition. 53 (39): 10420–10424. doi:10.1002/anie.201406721. PMID 25079606.
  13. ^ Ramachary, D. B.; Kishor, Mamillapalli (12 August 2008). "Direct amino acid-catalyzed cascade biomimetic reductive alkylations: application to the asymmetric synthesis of Hajos–Parrish ketone analogues". Organic & Biomolecular Chemistry. 6 (22): 4176–4187. doi:10.1039/B807999D. PMID 18972048.
  14. ^ Ramachary, D. B.; Vijayendar Reddy, Y. (2 December 2009). "A General Approach to Chiral Building Blocks via Direct Amino Acid-Catalyzed Cascade Three-Component Reductive Alkylations: Formal Total Synthesis of HIV-1 Protease Inhibitors, Antibiotic Agglomerins, Brefeldin A, and (R)-γ-Hexanolide". The Journal of Organic Chemistry. 75 (1): 74–85. doi:10.1021/jo901799n. PMID 19954143.
  15. ^ Ramachary, D. B.; Kishor, Mamillapalli (7 May 2010). "Direct catalytic asymmetric synthesis of highly functionalized tetronic acids/tetrahydro-isobenzofuran-1,5-diones via combination of cascade three-component reductive alkylations and Michael-aldol reactions". Organic & Biomolecular Chemistry. 8 (12): 2859–2867. doi:10.1039/C003588B. PMID 20454721.
  16. ^ Ramachary, D. B.; Anif Pasha, Mohammed B.; Thirupathi, Guguloth (7 August 2017). "Organocatalytic Asymmetric Formal [3+2] Cycloaddition as a Versatile Platform to Access Methanobenzo[7]annulenes". Angewandte Chemie International Edition. 56 (42): 12930–12934. doi:10.1002/anie.201706557. PMID 28783234.
  17. ^ Ramachary, D. B.; Ramakumar, Kinthada; Narayana, Vidadala V. F. (20 January 2007). "Organocatalytic Cascade Reactions Based on Push−Pull Dienamine Platform: Synthesis of Highly Substituted Anilines". The Journal of Organic Chemistry. 72 (4): 1458–1463. doi:10.1021/jo0623639. PMID 17288390.
  18. ^ Ramachary, D. B.; Ramakumar, Kinthada; Narayana, Vidadala V. F. (10 October 2008). "Amino Acid-Catalyzed Cascade [3+2]-Cycloaddition/Hydrolysis Reactions Based on the Push–Pull Dienamine Platform: Synthesis of Highly Functionalized NH-1,2,3-Triazoles". Chemistry – A European Journal. 14 (30): 9143–9147. doi:10.1002/chem.200801325. PMID 18767077.
  19. ^ Ramachary, D. B.; Ramakumar, Kinthada (9 March 2011). "Direct Organocatalytic Asymmetric Approach to Baylis–Hillman-Type Products Through a Push–Pull Dienamine Platform". European Journal of Organic Chemistry. 2011 (14): 2599–2605. doi:10.1002/ejoc.201100075.
  20. ^ Ramachary, D. B.; Vijayendar Reddy, V. (8 November 2011). "Dienamine Catalysis: An Emerging Technology in Organic Synthesis". European Journal of Organic Chemistry. 2012 (5): 865–887. doi:10.1002/ejoc.201101157.
  21. ^ Joseph, Jorly; Ramachary, D. B.; Jemmis, Eluvathingal D. (21 June 2006). "Electrostatic repulsion as an additional selectivity factor in asymmetric proline catalysis". Organic & Biomolecular Chemistry. 4 (14): 2685–2689. doi:10.1039/B606996G. PMID 16826292.
  22. ^ Ramachary, D. B.; Madhavachary, R. B.; ShivaPrasad, M. (10 February 2012). "Observation of neighboring ortho-hydroxyl group participation in organocatalytic asymmetric sequential Michael-lactonization reactions: synthesis of highly substituted chiral spirodihydrocoumarins". Organic & Biomolecular Chemistry. 10 (30): 5825–5829. doi:10.1039/C2OB07122C. PMID 22391626.
  23. ^ Ramachary, D. B.; Sakthidevi, Rajasekar B.; Shruthi, Kodambahalli S. (30 May 2012). "Asymmetric Supramolecular Catalysis: A Bio-Inspired Tool for the High Asymmetric Induction in the Enamine-Based Michael Reactions". Chemistry – A European Journal. 18 (26): 8008–8012. doi:10.1002/chem.201200962. PMID 22649025.
  24. ^ Jiang, G.; Liu, M.; Fang, D.; Tan, P.; Huang, M.; Zhou, T.; Jiang, Z.; Xu, Z.; Wang, Z. (28 February 2018). "A base promoted one pot solvent free version of the Ramachary reductive coupling/alkylation reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates". RSC Advances. 8 (16): 8961–8964. Bibcode:2018RSCAd...8.8961J. doi:10.1039/C8RA00326B. hdl:10072/384561.
  25. ^ Sangwan, R. B.; Javed; Dubey, A.; Mandal, P. K. (13 June 2017). "Organocatalytic [3+2] Cycloadditions: Toward Facile Synthesis of Sulfonyl-1,2,3-Triazolyl and Fully Substituted 1,2,3-Triazolyl Glycoconjugates". ChemistrySelect. 2 (17): 4733–4743. doi:10.1002/slct.201700805.
  26. ^ Aleman, J.; Cabrera, S. (15 November 2012). "Applications of asymmetric organocatalysis in medicinal chemistry". Chemical Society Reviews. 42 (2): 774–793. doi:10.1039/C2CS35380F. PMID 23154582.
  27. ^ Fraile, A.; Parra, A.; Tortosa, M.; Aleman, J. (2 December 2014). "Organocatalytic transformations of alkynals, alkynones, propriolates, and related electron-deficient alkynes". Tetrahedron. 70 (48): 9145–9173. doi:10.1016/j.tet.2014.07.023.
  28. ^ Peng, S.; Wang, Z.; Zhang, L.; Zhang, X.; Huang, Y. (25 January 2018). "Streamlined asymmetric α-difunctionalization of ynones". Nature Communications. 9 (1): 375. Bibcode:2018NatCo...9..375P. doi:10.1038/s41467-017-02801-9. PMC 5785506. PMID 29371601.
  29. ^ Liu, W.; Zou, L.; Fu, B.; Wang, X.; Wang, K.; Sun, Z.; Peng, F.; Wang, W.; Shao, Z. (29 August 2016). "Michael Donors in Chemo-, Enantio-, and γ-Selective 1,4-Conjugate Additions with Nitroolefins". The Journal of Organic Chemistry. 81 (18): 8296–8305. doi:10.1021/acs.joc.6b01425. PMID 27571411.
  30. ^ Schmidt, B.; Kunz, O. (16 December 2011). "One-Flask Tethered Ring Closing Metathesis–Electrocyclic Ring Opening for the Highly Stereoselective Synthesis of Conjugated Z/E-Dienes". European Journal of Organic Chemistry. 2012 (5): 1008–1018. doi:10.1002/ejoc.201101497.
  31. ^ Schmidt, B.; Kunz, O. (14 August 2013). "Stereoselective Synthesis of Dienyl Phosphonates via Extended Tethered Ring-Closing Metathesis". Organic Letters. 15 (17): 4470–4473. doi:10.1021/ol4020078. PMID 23944227.
  32. ^ "Breakthrough findings by University of Hyderabad professor". www.thehansindia.com. 7 November 2019. Retrieved 28 July 2023.
  33. ^ "Indian chemist has key chemical reactions named after him". www.thehindubusinessline.com. 6 November 2019. Retrieved 28 July 2023.
  34. ^ "Reaxys - An expert-curated chemistry database". www.elsevier.com. Retrieved 28 July 2023.
  35. ^ "Finding a green reaction for drugs: Why this UoH prof got invited to the Royal Society of Chemistry". Edex Live. 3 March 2020. Retrieved 28 July 2023.
  36. ^ Highlighted in News, Telangana Today, https://telanganatoday.com/honour-for-uoh-faculty-2
  37. ^ *Fellow - Indian Academy of Sciences, https://www.ias.ac.inpdescribe/fellow/Ramachary,_Prof._Dhevalapally_B
  38. ^ https://www.tasc.org.in/newly-elected-fellows.htm [dead link]
  39. ^ Ramachary, D. B. (2016). "CRSI Bronze Medals: P. S. Mukherjee, D. B. Ramachary, T. Govindaraju, and R. Gupta / SwarnaJayanti Fellowships: S. Ghosh and C. M. Reddy / Albrecht Kossel Prize: J. Buchner / DECHEMA Early-Career Researcher Prize: T. A. M. Gulder / Mattauch–Herzog Prize: K. Pagel / Honorary Doctorates: F. Schüth and T. J. Marks / Karl Max von Bauernfeind Medal: C. W. Kohlpaintner". Angewandte Chemie International Edition. 55 (27): 7578–7579. doi:10.1002/anie.201604544. PMID 27254753.
  40. ^ Previous Recipients of the BM Birla Science Prizes, https://www.birlasciencecentre.org/awards/previous-receipients-of-the-bm-birla-science-prizes/
  41. ^ Previous Recipients of Anil Kumar Bose Memorial Award, http://insaindia.res.in/youngmedal.php Archived 11 May 2021 at the Wayback Machine
  42. ^ Previous Recipients of Indian National Science Academy Medal for Young Scientist 2006, http://insaindia.res.in/youngmedal.php Archived 11 May 2021 at the Wayback Machine
  43. ^ Ramachary, D. B. "Author profile". European Journal of Organic Chemistry. 2018 (16): 1834. doi:10.1002/ejoc.201800182.
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