Dihydroxyphenylalanine transaminase
dihydroxyphenylalanine transaminase | |||||||||
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Identifiers | |||||||||
EC no. | 2.6.1.49 | ||||||||
CAS no. | 37277-98-8 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a dihydroxyphenylalanine transaminase (EC 2.6.1.49) is an enzyme that catalyzes the chemical reaction
- 3,4-dihydroxy-L-phenylalanine + 2-oxoglutarate 3,4-dihydroxyphenylpyruvate + L-glutamate
Thus, the two substrates of this enzyme are 3,4-dihydroxy-L-phenylalanine and 2-oxoglutarate, whereas its two products are 3,4-dihydroxyphenylpyruvate and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 3,4-dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase. Other names in common use include dopa transaminase, dihydroxyphenylalanine aminotransferase, aspartate-DOPP transaminase (ADT), L-dopa transaminase, dopa aminotransferase, glutamate-DOPP transaminase (GDT), phenylalanine-DOPP transaminase (PDT), DOPA 2-oxoglutarate aminotransferase, and DOPAATS. This enzyme participates in tyrosine metabolism. It employs one cofactor, pyridoxal phosphate.
References
- Fonnum F, Larsen K (1965). "Purification and properties of dihydroxyphenylalanine transaminase from guinea pig brain". J. Neurochem. 12 (7): 589–98. doi:10.1111/j.1471-4159.1965.tb04251.x. PMID 5829872.