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dnaS

From Wikipedia, the free encyclopedia


Deoxyuridine 5'-triphosphate nucleotidohydrolase
Identifiers
Symboldut
Alt. symbolsdnaS; ECK3630; JW3615; sof
NCBI gene948607
UniProtP06968
Other data
EC number3.6.1.23
Search for
StructuresSwiss-model
DomainsInterPro

dnaS or dut is a gene involved in DNA replication in Escherichia coli. It encodes dUTP nucleotidohydrolase, an enzyme responsible for catalyzing the conversion of dUTP to dUMP, thereby ensuring that the organism's DNA contains the nucleobase thymine instead of uracil.[1]

See also

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References

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  1. ^ el-Hajj HH, Zhang H, Weiss B (March 1988). "Lethality of a dut (deoxyuridine triphosphatase) mutation in Escherichia coli". Journal of Bacteriology. 170 (3): 1069–75. doi:10.1128/jb.170.3.1069-1075.1988. PMC 210875. PMID 2830228.