Draft:Mark Connors (physician)
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Submission declined on 16 May 2024 by HitroMilanese (talk). This submission is not adequately supported by reliable sources. Reliable sources are required so that information can be verified. If you need help with referencing, please see Referencing for beginners and Citing sources. Declined by HitroMilanese 3 months ago. | ![]() |
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Comment: Needs to be significantly rewritten to remove MOS:PUFFERY wording. Only primary sources are cited at time of review. ~Liancetalk 21:31, 10 June 2024 (UTC)
Comment: The title of this draft either has been disambiguated or will require disambiguation if accepted.If this draft has been disambiguated (renamed), submitters and reviewers are asked to consider whether the current title is the best possible disambiguation, and, if necessary, move (rename) this draft.If this draft is accepted, a hatnote will need to be added to the primary page to refer to this page. If there is already a hatnote on the primary page, please review whether a disambiguation page is in order instead. Please do not edit the primary page unless you are accepting this draft.The primary page is Mark Connors. Robert McClenon (talk) 19:20, 9 June 2024 (UTC)
Comment: Additional references in independent and reliable sources are needed to demonstrate notability. Hitro talk 13:22, 16 May 2024 (UTC)
Mark Connors | |
---|---|
Alma mater | Temple University (BA, MD) |
Known for | Research on Long-term nonprogressors |
Scientific career | |
Fields | Immunology |
Mark Connors is a researcher at the National Institutes of Health (NIH) specializing in HIV/AIDS. He serves as the Chief of the HIV-Specific Immunity Section at the National Institute of Allergy and Infectious Diseases (NIAID), where he oversees efforts to understand and enhance the immune response to HIV and other viruses. His research focuses on identifying effective immune responses to viruses, which are crucial for developing vaccines and immunotherapies.[1]
Career and Research
[edit]Dr. Connors received his medical degree from Temple University, followed by pediatric training at Tufts Medical Center, and infectious diseases training at NIAID and the Children's Hospital of Philadelphia. He has been with the NIH since 1989, initially studying the immune response to respiratory viruses before shifting his focus to HIV in 1994. His career highlights include pioneering studies on the immunologic control of HIV, particularly in Long-term nonprogressor or "elite controllers" who can control HIV without antiretroviral therapy. The study of this group of patients has provided insights for our understanding of an effective immune response to HIV and provided insights into potential strategies for HIV treatment and prevention.[1]
In addition to his work on the cellular immune response to HIV, he has made numerous contributions to our understanding of the antibody response. These include identifying patients with broad antibody responses to HIV, and from these patients isolating broad and potent monoclonal antibodies that define sites of vulnerability on HIV envelope protein. These antibodies include isolation of broad and potent antibodies 10E8, 35O22, and N6, among others a potent antibody which can neutralize nearly all HIV strains.[2][3][4]This discovery has broad implications for the development of HIV treatments and vaccines, as it targets a crucial part of the virus that attaches to immune cells, making it a promising candidate for therapeutic use.
Dr. Connors' work has not only contributed to our understanding of HIV but also has implications for broader immunological research and public health. His publications and contributions to the scientific community are recognized and continue to influence the field of HIV research.
References
[edit]- ^ a b "Mark Connors, M.D." NIAID. National Institutes of Health. 12 July 2022.
- ^ Huang, Jinghe; Kang, Byong H.; Pancera, Marie; Lee, Jeong Hyun; et al. (November 2014). "Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface". Nature. 515 (7525): 138–142. Bibcode:2014Natur.515..138H. doi:10.1038/nature13601. ISSN 0028-0836. PMC 4224615. PMID 25186731.
- ^ "NIH Scientists Identify Potent Antibody that Neutralizes Nearly All HIV Strains". Clinical Info. HIV.gov. 18 November 2016.
- ^ Huang, Jinghe; Ofek, Gilad; Laub, Leo; Louder, Mark K.; et al. (2012-11-15). "Broad and potent neutralization of HIV-1 by a gp41-specific human antibody". Nature. 491 (7424): 406–412. Bibcode:2012Natur.491..406H. doi:10.1038/nature11544. ISSN 0028-0836. PMC 4854285. PMID 23151583.
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