ELP3

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ELP3
Identifiers
Aliases ELP3, KAT9, elongator acetyltransferase complex subunit 3
External IDs MGI: 1921445 HomoloGene: 7105 GeneCards: ELP3
RNA expression pattern
PBB GE ELP3 221094 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253812
NM_028811

RefSeq (protein)

NP_001240741
NP_083087

Location (UCSC) Chr 8: 28.09 – 28.19 Mb Chr 14: 65.53 – 65.59 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Elongator complex protein 3, also named KAT9, is a protein that in humans is encoded by the ELP3 gene.[3][4] ELP3 is the catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. ELP3 supports the migration and branching of projection neurons through acetylation of alpha-tubulin in the developing cerebral cortex.[5] In mammals, ELP3 is important for paternal DNA demethylation after fertilization.[6] ELP3 is potentially involved in cellular redox homeostasis by mediating the acetylation of glucose-6-phosphate dehydrogenase.[7] Besides, ELP3 may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.


References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ (Jan 2002). "Purification and characterization of the human elongator complex". J Biol Chem. 277 (4): 3047–52. PMID 11714725. doi:10.1074/jbc.M110445200. 
  4. ^ "Entrez Gene: ELP3 elongation protein 3 homolog (S. cerevisiae)". 
  5. ^ Creppe C, Malinouskaya L, Volvert ML, Gillard M, Close P, Malaise O, Laguesse S, Cornez I, Rahmouni S, Ormenese S, Belachew S, Malgrange B, Chapelle JP, Siebenlist U, Moonen G, Chariot A, Nguyen L (Feb 2009). "Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin". Cell. 136 (3): 551–64. PMID 19185337. doi:10.1016/j.cell.2008.11.043. 
  6. ^ Okada Y, Yamagata K, Hong K, Wakayama T, Zhang Y (Jan 2010). "A role for the elongator complex in zygotic paternal genome demethylation". Nature. 463 (7280): 554–8. PMC 2834414Freely accessible. PMID 20054296. doi:10.1038/nature08732. 
  7. ^ Wang YP, Zhou LS, Zhao YZ, Wang SW, Chen LL, Liu LX, Ling ZQ, Hu FJ, Sun YP, Zhang JY, Yang C, Yang Y, Xiong Y, Guan KL, Ye D (Jun 2014). "Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress". The EMBO Journal. 33 (12): 1304–20. PMC 4194121Freely accessible. PMID 24769394. doi:10.1002/embj.201387224. 

Further reading[edit]