EME1

EME1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ZIU, 2ZIV, 2ZIW, 2ZIX, 4P0P, 4P0Q, 4P0R, 4P0S
Identifiers
Aliases	EME1, MMS4L, SLX2A, essential meiotic structure-specific endonuclease 1
External IDs	OMIM: 610885; MGI: 3576783; HomoloGene: 16123; GeneCards: EME1; OMA:EME1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	50,381,483 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	94,544,790 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; pancreatic ductal cell; ; oocyte; ; endothelial cell; ; secondary oocyte; ; duodenum; ; tibialis anterior muscle; ; ganglionic eminence; ; trabecular bone; ; caput epididymis;
	Top expressed in
	lateral part of occipital bone; ; somite; ; yolk sac; ; thyroid cartilage; ; maxillary prominence; ; sphenoid bone; ; abdominal wall; ; primitive streak; ; blastocyst; ; lesser wing of sphenoid bone;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; endonuclease activity; nuclease activity; protein binding; hydrolase activity; metal ion binding; endodeoxyribonuclease activity; crossover junction endodeoxyribonuclease activity;
Cellular component	nucleolus; nucleoplasm; nucleus; Holliday junction resolvase complex;
Biological process	cellular response to DNA damage stimulus; DNA recombination; interstrand cross-link repair; nucleic acid phosphodiester bond hydrolysis; response to intra-S DNA damage checkpoint signaling; DNA repair; resolution of meiotic recombination intermediates; double-strand break repair; replication fork processing; mitotic intra-S DNA damage checkpoint signaling;
	Sources:Amigo / QuickGO
Orthologs
	146956
	268465
	ENSG00000154920
	ENSMUSG00000039055
	Q96AY2
	Q8BJW7
	NM_001166131; NM_152463
	NM_177752; NM_001379688
	NP_001159603; NP_689676
	NP_808420; NP_001366617
	Wikidata
View/Edit Human	View/Edit Mouse

Crossover junction endonuclease EME1 is an enzyme that in humans is encoded by the EME1 gene.^[5]^[6] It forms a complex with MUS81 which resolves Holliday junctions. Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154920 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039055 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ciccia A, Constantinou A, West SC (Jun 2003). "Identification and characterization of the human mus81-eme1 endonuclease". J Biol Chem. 278 (27): 25172–8. doi:10.1074/jbc.M302882200. PMID 12721304.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: EME1 essential meiotic endonuclease 1 homolog 1 (S. pombe)".

References

Further reading