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Protein-coding gene in the species Homo sapiens
Alpha-hemoglobin-stabilizing protein is a protein that in humans is encoded by the ERAF gene .[ 3] [ 4] [ 5]
^ a b c GRCh38: Ensembl release 89: ENSG00000169877 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Miele G, Manson J, Clinton M (Mar 2001). "A novel erythroid-specific marker of transmissible spongiform encephalopathies". Nat Med . 7 (3): 361–4. doi :10.1038/85515 . PMID 11231637 . S2CID 11499070 .
^ Kihm AJ, Kong Y, Hong W, Russell JE, Rouda S, Adachi K, Simon MC, Blobel GA, Weiss MJ (Jun 2002). "An abundant erythroid protein that stabilizes free alpha-haemoglobin". Nature . 417 (6890): 758–63. Bibcode :2002Natur.417..758K . doi :10.1038/nature00803 . PMID 12066189 . S2CID 4362675 .
^ "Entrez Gene: ERAF erythroid associated factor" .
Florio P, Rossi M, Sigurdardottir M, et al. (2004). "Paracrine regulation of endometrial function: interaction between progesterone and corticotropin-releasing factor (CRF) and activin A". Steroids . 68 (10–13): 801–7. doi :10.1016/S0039-128X(03)00137-5 . PMID 14667971 . S2CID 20953018 .
Weiss MJ, Zhou S, Feng L, et al. (2006). "Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia". Ann. N. Y. Acad. Sci . 1054 : 103–17. doi :10.1196/annals.1345.013 . PMID 16339656 . S2CID 23597786 .
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Viprakasit V, Tanphaichitr VS, Chinchang W, et al. (2004). "Evaluation of alpha hemoglobin stabilizing protein (AHSP) as a genetic modifier in patients with beta thalassemia" . Blood . 103 (9): 3296–9. doi :10.1182/blood-2003-11-3957 . PMID 14715623 .
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Hamdane D, Vasseur-Godbillon C, Baudin-Creuza V, et al. (2007). "Reversible hexacoordination of alpha-hemoglobin-stabilizing protein (AHSP)/alpha-hemoglobin Versus pressure. Evidence for protection of the alpha-chains by their chaperone" . J. Biol. Chem . 282 (9): 6398–404. doi :10.1074/jbc.M610543200 . PMID 17194704 .
PDB gallery
1w09 : SOLUTION STRUCTURE OF THE CIS FORM OF THE HUMAN ALPHA-HEMOGLOBIN STABILIZING PROTEIN (AHSP)
1w0a : SOLUTION STRUCTURE OF THE TRANS FORM OF THE HUMAN ALPHA-HEMOGLOBIN STABILIZING PROTEIN (AHSP)
1w0b : SOLUTION STRUCTURE OF THE HUMAN ALPHA-HEMOGLOBIN STABILIZING PROTEIN (AHSP) P30A MUTANT
1xzy : Solution structure of the P30-trans form of Alpha Hemoglobin Stabilizing Protein (AHSP)
1y01 : Crystal structure of AHSP bound to Fe(II) alpha-hemoglobin
1z8u : Crystal structure of oxidized alpha hemoglobin bound to AHSP