ETFA

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ETFA
Protein ETFA PDB 1efv.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ETFA, EMA, GA2, MADD, electron transfer flavoprotein alpha subunit
External IDs MGI: 106092 HomoloGene: 100 GeneCards: ETFA
Genetically Related Diseases
rheumatoid arthritis[1]
RNA expression pattern
PBB GE ETFA 201931 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000126
NM_001127716

NM_145615

RefSeq (protein)

NP_000117
NP_001121188

NP_663590.3
NP_663590

Location (UCSC) Chr 15: 76.22 – 76.31 Mb Chr 9: 55.45 – 55.51 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Electron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II), also known as ETFA, is a protein which in humans is encoded by the ETFA gene.[4]

ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids.[4]

References[edit]

Further reading[edit]