EXOC2

EXOC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HK6
Identifiers
Aliases	EXOC2, SEC5, SEC5L1, Sec5p, exocyst complex component 2, NEDFACH
External IDs	OMIM: 615329; MGI: 1913732; HomoloGene: 10122; GeneCards: EXOC2; OMA:EXOC2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	693,139 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	31,158,076 bp
RNA expression pattern
	Top expressed in
	testicle; ; middle temporal gyrus; ; gonad; ; secondary oocyte; ; Brodmann area 23; ; islet of Langerhans; ; ganglionic eminence; ; Achilles tendon; ; stromal cell of endometrium; ; primary visual cortex;
	Top expressed in
	hand; ; genital tubercle; ; otolith organ; ; utricle; ; superior cervical ganglion; ; granulocyte; ; zygote; ; spermatocyte; ; spermatid; ; tail of embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein kinase binding; protein N-terminus binding;
Cellular component	cytosol; plasma membrane; exocyst; membrane; Flemming body;
Biological process	protein transport; regulation of entry of bacterium into host cell; Golgi to plasma membrane transport; exocyst assembly; exocytosis; transport; vesicle-mediated transport;
	Sources:Amigo / QuickGO
Orthologs
	55770
	66482
	ENSG00000112685
	ENSMUSG00000021357
	Q96KP1
	Q9D4H1
	NM_018303
	NM_025588; NM_001360093
	NP_060773
	NP_079864; NP_001347022
	Wikidata
View/Edit Human	View/Edit Mouse

Exocyst complex component 2 is a protein that in humans is encoded by the EXOC2 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112685 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021357 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Murthy M, Garza D, Scheller RH, Schwarz TL (Feb 2003). "Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists". Neuron. 37 (3): 433–47. doi:10.1016/S0896-6273(03)00031-X. PMID 12575951.
^ Sjolinder M, Uhlmann J, Ponstingl H (Dec 2002). "DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion". FEBS Lett. 532 (1–2): 211–5. doi:10.1016/S0014-5793(02)03677-3. PMID 12459492.
^ "Entrez Gene: EXOC2 exocyst complex component 2".