White began his professional football career with the Minnesota Vikings after being drafted in the second round of the 1969 AFL/NFL draft. He is one of 11 players to have played in all four Vikings Super Bowl appearances between 1969 and 1976. Before the 1978 season, he was traded to the San Diego Chargers, with whom he played until 1985 when he retired after seventeen years and 241 games. Mainly used at offensive guard, he was selected to the Pro Bowl four times. He played as an offensive lineman for the Chargers 1978-85.
After retiring from the NFL, White worked as a football coach.
Charger quarterback Dan Fouts has been vocal about endorsing White for the Pro Football Hall of Fame: “When he retired, nobody had played in more games (241) as an offensive lineman than Ed White. They don’t have any statistics for offensive linemen other than Pro Bowls and Super Bowls, and those are things Ed has done. He was one of the most feared offensive linemen in the game. You talk to guys like Howie Long and Matt Millen who had to go against Big Ed. They hated it.” Chargers center/guard Dennis McKnight has called White “probably the best all-around offensive lineman in the league in terms of run blocking and pass blocking.” Kansas City Chiefs offensive tackle Kyle Turley has called White the best coach he'd ever had.