- "Siskiyou willowherb" redirects here. Not to be confused with E. rigidum, sometimes called "Siskiyou Mountains willowherb".
The plant is endemic to the Klamath Mountains of far northern California and southern Oregon. It grows in mountain habitats, including alpine talus and subalpine coniferous forest, often on serpentine soils.
Epilobium siskiyouense is a small, clumping subshrub growing scaly, often densely hairy and glandular from a woody caudex reaching up to about 25 centimeters in maximum height. The leaves are lance-shaped to oval and under 3 centimeters long.
The glandular inflorescence bears bright to deep pink flowers with petals 1 or 2 centimeters long. The fruit is a hairy capsule reaching up to 4.5 centimeters in length.
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