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Exonuclease 5

From Wikipedia, the free encyclopedia
EXO5
Identifiers
AliasesEXO5, C1orf176, DEM1, Exo V, hExo5, exonuclease 5
External IDsMGI: 1920422; HomoloGene: 41497; GeneCards: EXO5; OMA:EXO5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001160043
NM_028457

RefSeq (protein)

NP_001153515
NP_082733

Location (UCSC)Chr 1: 40.51 – 40.52 MbChr 4: 120.78 – 120.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Exonuclease 5 is a protein that in humans is encoded by the EXO5 gene. [5]

Function

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The protein encoded by this gene is a single-stranded DNA (ssDNA)-specific exonuclease that can slide along the DNA before cutting it. However, human replication protein A binds ssDNA and restricts sliding of the encoded protein, providing a 5'-directionality to the enzyme. This protein localizes to nuclear repair loci after DNA damage. [provided by RefSeq, Nov 2016].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164002Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028629Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Exonuclease 5". Retrieved 2018-04-27.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.