EFEMP2

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EFEMP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEFEMP2, ARCL1B, FBLN4, MBP1, UPH1, EGF containing fibulin like extracellular matrix protein 2, EGF containing fibulin extracellular matrix protein 2
External IDsOMIM: 604633 MGI: 1891209 HomoloGene: 32339 GeneCards: EFEMP2
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for EFEMP2
Genomic location for EFEMP2
Band11q13.1Start65,866,441 bp[1]
End65,873,592 bp[1]
RNA expression pattern
PBB GE EFEMP2 209356 x at fs.png

PBB GE EFEMP2 206580 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016938

NM_001164352
NM_021474

RefSeq (protein)

NP_058634

NP_001157824
NP_067449

Location (UCSC)Chr 11: 65.87 – 65.87 MbChr 19: 5.47 – 5.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

EGF-containing fibulin-like extracellular matrix protein 2 is a protein that in humans is encoded by the EFEMP2 gene.[5][6][7]

A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. EFEMP2 (also known as fibulin-4) contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is widely expressed in a range of adult and fetal tissues.[7]

Interactions[edit]

EFEMP2 has been shown to interact with P53.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172638 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024909 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Giltay R, Timpl R, Kostka G (Feb 2000). "Sequence, recombinant expression and tissue localization of two novel extracellular matrix proteins, fibulin-3 and fibulin-4". Matrix Biol. 18 (5): 469–80. doi:10.1016/S0945-053X(99)00038-4. PMID 10601734.
  6. ^ Katsanis N, Venable S, Smith JR, Lupski JR (Sep 2000). "Isolation of a paralog of the Doyne honeycomb retinal dystrophy gene from the multiple retinopathy critical region on 11q13". Hum Genet. 106 (1): 66–72. doi:10.1007/s004390051011. PMID 10982184.
  7. ^ a b "Entrez Gene: EFEMP2 EGF-containing fibulin-like extracellular matrix protein 2".
  8. ^ Gallagher, W M; Argentini M; Sierra V; Bracco L; Debussche L; Conseiller E (Jun 1999). "MBP1: a novel mutant p53-specific protein partner with oncogenic properties". Oncogene. 18 (24): 3608–16. doi:10.1038/sj.onc.1202937. ISSN 0950-9232. PMID 10380882.

Further reading[edit]

External links[edit]