FBXO32

FBXO32
Identifiers
Aliases	FBXO32, Fbx32, MAFbx, F-box protein 32
External IDs	OMIM: 606604; MGI: 1914981; HomoloGene: 12182; GeneCards: FBXO32; OMA:FBXO32 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q24.13 Start 123,497,889 bp End 123,541,206 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 D1 Start 58,039,275 bp End 58,078,328 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardiac muscle tissue of right atrium deltoid muscle tibialis anterior muscle myocardium of left ventricle gastrocnemius muscle quadriceps femoris muscle vastus lateralis muscle gastric mucosa biceps brachii Skeletal muscle tissue of biceps brachii Top expressed in muscle of thigh skeletal muscle tissue quadriceps femoris muscle esophagus urinary bladder uterus zone of skin heart lip cochlea More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding ubiquitin-protein transferase activity Cellular component cytoplasm Z discdkac nucleoplasm cytosol nucleus SCF ubiquitin ligase complex Biological process response to denervation involved in regulation of muscle adaptation cellular response to dexamethasone stimulus protein polyubiquitination protein ubiquitination post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114907 67731 Ensembl ENSG00000156804 ENSMUSG00000022358 UniProt Q969P5 Q9CPU7 RefSeq (mRNA) NM_148177 NM_001242463 NM_058229 NM_026346 RefSeq (protein) NP_001229392 NP_478136 NP_680482 NP_080622 Location (UCSC) Chr 8: 123.5 – 123.54 Mb Chr 15: 58.04 – 58.08 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

F-box only protein 32 is a protein that in humans is encoded by the FBXO32 gene.

Function

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing of this gene results in two transcript variants encoding two isoforms of different sizes.

Interactions

FBXO32 has been shown to interact with EIF3A.

Further reading

• Hanai J, Cao P, Tanksale P, Imamura S, Koshimizu E, Zhao J, Kishi S, Yamashita M, Phillips PS, Sukhatme VP, Lecker SH (2007). "The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity". J. Clin. Invest. 117 (12): 3940–51. doi:10.1172/JCI32741. PMC 2066198. PMID 17992259.
• de Palma L, Marinelli M, Pavan M, Orazi A (2008). "Ubiquitin ligases MuRF1 and MAFbx in human skeletal muscle atrophy". Joint Bone Spine. 75 (1): 53–7. doi:10.1016/j.jbspin.2007.04.019. PMID 17977773.
• Mascher H, Tannerstedt J, Brink-Elfegoun T, Ekblom B, Gustafsson T, Blomstrand E (2008). "Repeated resistance exercise training induces different changes in mRNA expression of MAFbx and MuRF-1 in human skeletal muscle". Am. J. Physiol. Endocrinol. Metab. 294 (1): E43-51. doi:10.1152/ajpendo.00504.2007. PMID 17971512.
• de Boer MD, Selby A, Atherton P, Smith K, Seynnes OR, Maganaris CN, Maffulli N, Movin T, Narici MV, Rennie MJ (2007). "The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse". J. Physiol. (Lond.). 585 (Pt 1): 241–51. doi:10.1113/jphysiol.2007.142828. PMC 2375459. PMID 17901116.
• Petersen AM, Magkos F, Atherton P, Selby A, Smith K, Rennie MJ, Pedersen BK, Mittendorfer B (2007). "Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle". Am. J. Physiol. Endocrinol. Metab. 293 (3): E843-8. doi:10.1152/ajpendo.00301.2007. PMID 17609255.
• Kostek MC, Chen YW, Cuthbertson DJ, Shi R, Fedele MJ, Esser KA, Rennie MJ (2007). "Gene expression responses over 24 h to lengthening and shortening contractions in human muscle: major changes in CSRP3, MUSTN1, SIX1, and FBXO32". Physiol. Genomics. 31 (1): 42–52. doi:10.1152/physiolgenomics.00151.2006. PMID 17519359.
• Doucet M, Russell AP, Léger B, Debigaré R, Joanisse DR, Caron MA, LeBlanc P, Maltais F (2007). "Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease". Am. J. Respir. Crit. Care Med. 176 (3): 261–9. doi:10.1164/rccm.200605-704OC. PMID 17478621.
• Ogawa T, Furochi H, Mameoka M, Hirasaka K, Onishi Y, Suzue N, Oarada M, Akamatsu M, Akima H, Fukunaga T, Kishi K, Yasui N, Ishidoh K, Fukuoka H, Nikawa T (2006). "Ubiquitin ligase gene expression in healthy volunteers with 20-day bedrest". Muscle Nerve. 34 (4): 463–9. doi:10.1002/mus.20611. PMID 16868939.
• Léger B, Vergani L, Sorarù G, Hespel P, Derave W, Gobelet C, D'Ascenzio C, Angelini C, Russell AP (2006). "Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1". FASEB J. 20 (3): 583–5. doi:10.1096/fj.05-5249fje. PMID 16507768.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.