FBXW4

FBXW4
Identifiers
Aliases	FBXW4, DAC, FBW4, FBWD4, SHFM3, SHSF3, F-box and WD repeat domain containing 4
External IDs	OMIM: 608071; MGI: 1354698; HomoloGene: 32197; GeneCards: FBXW4; OMA:FBXW4 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	101,695,295 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	45,648,751 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; apex of heart; ; amygdala; ; putamen; ; inferior ganglion of vagus nerve; ; muscle layer of sigmoid colon; ; gastrocnemius muscle; ; muscle of thigh; ; subthalamic nucleus; ; gastric mucosa;
	Top expressed in
	secondary oocyte; ; primary oocyte; ; zygote; ; retinal pigment epithelium; ; granulocyte; ; choroid plexus of fourth ventricle; ; muscle of thigh; ; neural layer of retina; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein binding; molecular function;
Cellular component	ubiquitin ligase complex; cytosol; SCF ubiquitin ligase complex;
Biological process	multicellular organism development; embryonic digit morphogenesis; cartilage development; positive regulation of mesenchymal cell proliferation; Wnt signaling pathway; embryonic limb morphogenesis; ubiquitin-dependent protein catabolic process; limb development; protein polyubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	6468
	30838
	ENSG00000107829
	ENSMUSG00000040913
	P57775
	Q9JMJ2
	NM_022039; NM_001323541
	NM_013907
	NP_001310470; NP_071322
	NP_038935
	Wikidata
View/Edit Human	View/Edit Mouse

F-box/WD repeat-containing protein 4 is a protein that in humans is encoded by the FBXW4 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107829 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040913 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gurrieri F, Prinos P, Tackels D, Kilpatrick MW, Allanson J, Genuardi M, Vuckov A, Nanni L, Sangiorgi E, Garofalo G, Nunes ME, Neri G, Schwartz C, Tsipouras P (Oct 1996). "A split hand-split foot (SHFM3) gene is located at 10q24-->25". Am J Med Genet. 62 (4): 427–36. doi:10.1002/(SICI)1096-8628(19960424)62:4<427::AID-AJMG16>3.0.CO;2-Q. PMID 8723077.
^ Palmer SE, Scherer SW, Kukolich M, Wijsman EM, Tsui LC, Stephens K, Evans JP (Jul 1994). "Evidence for locus heterogeneity in human autosomal dominant split hand/split foot malformation". Am J Hum Genet. 55 (1): 21–6. PMC 1918225. PMID 7912888.
^ "Entrez Gene: FBXW4 F-box and WD repeat domain containing 4".

References

Further reading