FBXW8

FBXW8
Identifiers
Aliases	FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6, F-box and WD repeat domain containing 8
External IDs	OMIM: 609073; MGI: 1923041; HomoloGene: 17731; GeneCards: FBXW8; OMA:FBXW8 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	117,031,148 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	118,293,529 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; gonad; ; ventricular zone; ; bone marrow cells; ; islet of Langerhans; ; ganglionic eminence; ; epithelium of colon; ; testicle; ; popliteal artery; ; tibial arteries;
	Top expressed in
	otic vesicle; ; otic placode; ; saccule; ; interventricular septum; ; internal carotid artery; ; external carotid artery; ; somite; ; calvaria; ; yolk sac; ; lumbar spinal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin-protein transferase activity;
Cellular component	perinuclear region of cytoplasm; Golgi apparatus; Cul7-RING ubiquitin ligase complex; SCF ubiquitin ligase complex; 3M complex; cytoplasm; cytosol;
Biological process	cell population proliferation; positive regulation of dendrite morphogenesis; spongiotrophoblast layer development; labyrinthine layer blood vessel development; Golgi organization; protein ubiquitination; protein polyubiquitination; post-translational protein modification; positive regulation of transcription factor catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	26259
	231672
	ENSG00000174989
	ENSMUSG00000032867
	Q8N3Y1
	Q8BIA4
	NM_012174; NM_153348
	NM_172721
	NP_036306; NP_699179
	NP_766309
	Wikidata
View/Edit Human	View/Edit Mouse

F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174989 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032867 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
^ "Entrez Gene: FBXW8 F-box and WD repeat domain containing 8".

References

Further reading