FBXW8

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FBXW8
Identifiers
Aliases FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6, F-box and WD repeat domain containing 8
External IDs MGI: 1923041 HomoloGene: 17731 GeneCards: FBXW8
RNA expression pattern
PBB GE FBXW8 gnf1h08761 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012174
NM_153348

NM_172721

RefSeq (protein)

NP_036306
NP_699179

NP_766309.2
NP_766309

Location (UCSC) Chr 12: 116.91 – 117.03 Mb Chr 5: 118.06 – 118.16 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene.[3][4][5]

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin-protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. 
  4. ^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. 
  5. ^ a b "Entrez Gene: FBXW8 F-box and WD repeat domain containing 8". 

Further reading[edit]