FCRLA

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FCRLA
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FCRLA, FCRL, FCRL1, FCRLM1, FCRLX, FCRLb, FCRLc1, FCRLc2, FCRLd, FCRLe, FCRX, FREB, Fc receptor like A
External IDs MGI: 2138647 HomoloGene: 13106 GeneCards: FCRLA
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001160215
NM_145141

RefSeq (protein)

NP_001153687.1
NP_660123.1
NP_001153687
NP_660123

Location (UCSC) Chr 1: 161.71 – 161.71 Mb Chr 1: 170.92 – 170.93 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Fc receptor-like A is a protein that in humans is encoded by the FCRLA gene.[3][4]

Receptors for the Fc fragment of IgG, or FCGRs (see MIM 146790), are cell surface glycoproteins of the Ig superfamily (IgSF). These receptors mediate phagocytosis of IgG-coated pathogens and promote activation of effector cells, leading to inflammatory responses and antibody-mediated cellular cytotoxicity. All FCGR genes map to human chromosome 1. Additional genes in this region, including FREB, encode FCGR homologs that are selectively expressed in B cells and may be implicated in B-cell development and lymphomagenesis.[supplied by OMIM][4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Mechetina LV, Najakshin AM, Volkova OY, Guselnikov SV, Faizulin RZ, Alabyev BY, Chikaev NA, Vinogradova MS, Taranin AV (Dec 2001). "FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features". Eur J Immunol. 32 (1): 87–96. doi:10.1002/1521-4141(200201)32:1<87::AID-IMMU87>3.0.CO;2-#. PMID 11754007. 
  4. ^ a b "Entrez Gene: FCRLA Fc receptor-like A". 

Further reading[edit]