FGFR1OP

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FGFR1OP
Protein FGFR1OP PDB 2d68.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FGFR1OP, FOP, FGFR1 oncogene partner
External IDs MGI: 1922546 HomoloGene: 5116 GeneCards: FGFR1OP
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_194429
NM_001278690
NM_007045

NM_001197046
NM_201230

RefSeq (protein)

NP_008976.1
NP_919410.1

NP_001183975.1
NP_957682.1

Location (UCSC) Chr 6: 167 – 167.05 Mb Chr 17: 8.17 – 8.2 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

FGFR1 oncogene partner is a protein that in humans is encoded by the FGFR1OP gene.[3][4][5]

This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Popovici C, Zhang B, Gregoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, Pebusque MJ (Mar 1999). "The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1". Blood. 93 (4): 1381–9. PMID 9949182. 
  4. ^ Reither A, Hehlmann R, Goldman JM, Cross NC (Aug 1999). "[The 8p11 myeloproliferative syndrome]". Med Klin (Munich). 94 (4): 207–10. PMID 10373756. 
  5. ^ a b "Entrez Gene: FGFR1OP FGFR1 oncogene partner". 

Further reading[edit]