FGFR1OP

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FGFR1 oncogene partner
Protein FGFR1OP PDB 2d68.png
PDB rendering based on 2d68.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FGFR1OP ; FOP
External IDs OMIM605392 MGI1922546 HomoloGene5116 GeneCards: FGFR1OP Gene
Orthologs
Species Human Mouse
Entrez 11116 75296
Ensembl ENSG00000213066 ENSMUSG00000069135
UniProt O95684 Q66JX5
RefSeq (mRNA) NM_001278690 NM_001197046
RefSeq (protein) NP_001265619 NP_001183975
Location (UCSC) Chr 6:
167 – 167.05 Mb
Chr 17:
8.17 – 8.2 Mb
PubMed search [1] [2]

FGFR1 oncogene partner is a protein that in humans is encoded by the FGFR1OP gene.[1][2][3]

This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.[3]

References[edit]

  1. ^ Popovici C, Zhang B, Gregoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, Pebusque MJ (Mar 1999). "The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1". Blood 93 (4): 1381–9. PMID 9949182. 
  2. ^ Reither A, Hehlmann R, Goldman JM, Cross NC (Aug 1999). "[The 8p11 myeloproliferative syndrome]". Med Klin (Munich) 94 (4): 207–10. PMID 10373756. 
  3. ^ a b "Entrez Gene: FGFR1OP FGFR1 oncogene partner". 

Further reading[edit]