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FHOD1

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FHOD1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFHOD1, FHOS, formin homology 2 domain containing 1
External IDsOMIM: 606881; MGI: 2679008; HomoloGene: 40860; GeneCards: FHOD1; OMA:FHOD1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013241
NM_001318202

NM_177699

RefSeq (protein)

NP_001305131
NP_037373

NP_808367

Location (UCSC)Chr 16: 67.23 – 67.25 MbChr 8: 106.06 – 106.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FH1/FH2 domain-containing protein 1 is a protein that in humans is encoded by the FHOD1 gene.[5][6][7]

This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines.[7]

Interactions

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FHOD1 has been shown to interact with RAC1.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135723Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014778Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Westendorf JJ, Mernaugh R, Hiebert SW (May 1999). "Identification and characterization of a protein containing formin homology (FH1/FH2) domains". Gene. 232 (2): 173–82. doi:10.1016/S0378-1119(99)00127-4. PMID 10352228.
  6. ^ Boehm MB, Milius TJ, Zhou Y, Westendorf JJ, Koka S (October 2005). "The mammalian formin FHOD1 interacts with the ERK MAP kinase pathway". Biochemical and Biophysical Research Communications. 335 (4): 1090–4. doi:10.1016/j.bbrc.2005.07.191. PMID 16112087.
  7. ^ a b "Entrez Gene: FHOD1 formin homology 2 domain containing 1".
  8. ^ Westendorf JJ (December 2001). "The formin/diaphanous-related protein, FHOS, interacts with Rac1 and activates transcription from the serum response element". The Journal of Biological Chemistry. 276 (49): 46453–9. doi:10.1074/jbc.M105162200. PMID 11590143.

Further reading

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