Folylpolyglutamate synthase

FPGS
Identifiers
Aliases	FPGS, folylpolyglutamate synthase
External IDs	OMIM: 136510; MGI: 95576; HomoloGene: 6997; GeneCards: FPGS; OMA:FPGS - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q34.11 Start 127,794,597 bp End 127,814,327 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 B|2 22.09 cM Start 32,572,621 bp End 32,594,157 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary right ovary left uterine tube gastric mucosa left adrenal cortex right uterine tube right lobe of liver right adrenal gland right adrenal cortex canal of the cervix Top expressed in left lobe of liver zygote secondary oocyte right kidney proximal tubule primary oocyte spermatid tail of embryo yolk sac epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ligase activity ATP binding tetrahydrofolylpolyglutamate synthase activity metal ion binding dihydrofolate synthase activity Cellular component cytosol membrane mitochondrial inner membrane cytoplasm mitochondrion mitochondrial matrix Biological process one-carbon metabolic process biosynthesis brain development folic acid metabolic process animal organ regeneration liver development glutamate metabolic process cell population proliferation nucleobase-containing compound metabolic process folic acid-containing compound biosynthetic process folic acid-containing compound metabolic process tetrahydrofolylpolyglutamate biosynthetic process dihydrofolate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2356 14287 Ensembl ENSG00000136877 ENSMUSG00000009566 UniProt Q05932 P48760 RefSeq (mRNA) NM_001018078 NM_001288803 NM_004957 NM_010236 RefSeq (protein) NP_001018088 NP_001275732 NP_004948 NP_034366 Location (UCSC) Chr 9: 127.79 – 127.81 Mb Chr 2: 32.57 – 32.59 Mb PubMed search
Wikidata
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Folylpolyglutamate synthase, mitochondrial is an enzyme that in humans is encoded by the FPGS gene.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit