G6B

MPIG6B
Identifiers
Aliases	MPIG6B, G6b, NG31, C6orf25, G6B, chromosome 6 open reading frame 25, G6b-B, megakaryocyte and platelet inhibitory receptor G6b, THAMY
External IDs	OMIM: 606520; MGI: 2146995; HomoloGene: 82249; GeneCards: MPIG6B; OMA:MPIG6B - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	31,726,714 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	35,285,160 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; bone marrow cells; ; skin of leg; ; skin of abdomen; ; testicle; ; right lung; ; epithelium of colon; ; spleen;
	Top expressed in
	bone marrow; ; spleen; ; embryo; ; blastocyst; ; lip; ; morula; ; ventricle; ; testicle; ; epiblast; ; zone of skin;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heparin binding; protein binding;
Cellular component	integral component of membrane; plasma membrane; endoplasmic reticulum; membrane; Golgi apparatus;
Biological process	platelet activation; negative regulation of signal transduction; integrin-mediated signaling pathway; blood coagulation; erythrocyte differentiation; megakaryocyte differentiation; platelet formation; megakaryocyte development;
	Sources:Amigo / QuickGO
Orthologs
	80739
	106722
ENSG00000206396; ENSG00000224393; ENSG00000204420; ENSG00000237459; ENSG00000230060;
	ENSG00000228090; ENSG00000231003
	ENSMUSG00000073414
	O95866
	D7PDD4
NM_025260; NM_138272; NM_138273; NM_138274; NM_138275;
	NM_138276; NM_138277
	NM_001033221; NM_001191012
NP_079536; NP_612116; NP_612117; NP_612118; NP_612119;
	NP_612121; NP_079536.2; NP_612116.1; NP_612117.1; NP_612118.1; NP_612119.1; NP_612121.1
	NP_001028393; NP_001177941
	Wikidata
View/Edit Human	View/Edit Mouse

Protein G6b is a protein that in humans is encoded by the G6B gene, or C6orf25.^[5]^[6]^[7]

This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene.^[7]

References

^ ^a ^b ^c ENSG00000224393, ENSG00000204420, ENSG00000237459, ENSG00000230060, ENSG00000228090, ENSG00000231003 GRCh38: Ensembl release 89: ENSG00000206396, ENSG00000224393, ENSG00000204420, ENSG00000237459, ENSG00000230060, ENSG00000228090, ENSG00000231003 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000073414 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ribas G, Neville M, Wixon JL, Cheng J, Campbell RD (Jul 1999). "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region". J Immunol. 163 (1): 278–87. doi:10.4049/jimmunol.163.1.278. PMID 10384126.
^ de Vet EC, Aguado B, Campbell RD (Nov 2001). "G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2". J Biol Chem. 276 (45): 42070–6. doi:10.1074/jbc.M103214200. PMID 11544253.
^ ^a ^b "Entrez Gene: C6orf25 chromosome 6 open reading frame 25".

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
de Vet EC, Newland SA, Lyons PA, et al. (2005). "The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin". FEBS Lett. 579 (11): 2355–8. Bibcode:2005FEBSL.579.2355D. doi:10.1016/j.febslet.2005.03.032. PMID 15848171. S2CID 24445026.
Newland SA, Macaulay IC, Floto AR, et al. (2007). "The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro". Blood. 109 (11): 4806–9. doi:10.1182/blood-2006-09-047449. PMID 17311996.
Li J, Cadeiras M, Prinz von Bayern M, et al. (2007). "G6b-B cell surface inhibitory receptor expression is highly restricted to CD4+ T-cells and induced by interleukin-4-activated STAT6 pathway". Hum. Immunol. 68 (8): 708–14. doi:10.1016/j.humimm.2007.04.008. PMID 17678728.

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[refGRCh38Ensembl-1] ENSG00000224393, ENSG00000204420, ENSG00000237459, ENSG00000230060, ENSG00000228090, ENSG00000231003 GRCh38: Ensembl release 89: ENSG00000206396, ENSG00000224393, ENSG00000204420, ENSG00000237459, ENSG00000230060, ENSG00000228090, ENSG00000231003 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000073414 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10384126-5] Ribas G, Neville M, Wixon JL, Cheng J, Campbell RD (Jul 1999). "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region". J Immunol. 163 (1): 278–87. doi:10.4049/jimmunol.163.1.278. PMID 10384126.

[pmid11544253-6] Vet EC, Aguado B, Campbell RD (Nov 2001). "G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2". J Biol Chem. 276 (45): 42070–6. doi:10.1074/jbc.M103214200. PMID 11544253.

[entrez-7] "Entrez Gene: C6orf25 chromosome 6 open reading frame 25".

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References

Further reading