GAL3ST2

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GAL3ST2
Identifiers
Aliases GAL3ST2, GAL3ST-2, GP3ST, galactose-3-O-sulfotransferase 2
External IDs MGI: 3646771 HomoloGene: 41471 GeneCards: GAL3ST2
RNA expression pattern
PBB GE GAL3ST2 gnf1h00397 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022134

NM_001039219

RefSeq (protein)

NP_071417

n/a

Location (UCSC) Chr 2: 241.78 – 241.8 Mb Chr 1: 93.99 – 94.02 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Galactose-3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the GAL3ST2 gene.[3][4]

This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides with similar efficiencies, and on core 1 glycans. This enzyme has been implicated in tumor metastasis processes. This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Honke K, Tsuda M, Koyota S, Wada Y, Iida-Tanaka N, Ishizuka I, Nakayama J, Taniguchi N (Feb 2001). "Molecular cloning and characterization of a human beta-Gal-3'-sulfotransferase that acts on both type 1 and type 2 (Gal beta 1-3/1-4GlcNAc-R) oligosaccharides". J Biol Chem. 276 (1): 267–74. doi:10.1074/jbc.M005666200. PMID 11029462. 
  4. ^ a b "Entrez Gene: GAL3ST2 galactose-3-O-sulfotransferase 2". 

Further reading[edit]