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GAL3ST2

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(Redirected from GAL3ST2 (gene))
GAL3ST2
Identifiers
AliasesGAL3ST2, GAL3ST-2, GP3ST, galactose-3-O-sulfotransferase 2
External IDsOMIM: 608237; MGI: 2685834; HomoloGene: 41471; GeneCards: GAL3ST2; OMA:GAL3ST2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022134

NM_199366

RefSeq (protein)

NP_071417

NP_001192178

Location (UCSC)Chr 2: 241.78 – 241.8 MbChr 1: 93.79 – 93.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Galactose-3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the GAL3ST2 gene.[5][6]

This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides with similar efficiencies, and on core 1 glycans. This enzyme has been implicated in tumor metastasis processes. This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2.[6]

References

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  1. ^ a b c ENSG00000276126 GRCh38: Ensembl release 89: ENSG00000154252, ENSG00000276126Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000094651Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Honke K, Tsuda M, Koyota S, Wada Y, Iida-Tanaka N, Ishizuka I, Nakayama J, Taniguchi N (Feb 2001). "Molecular cloning and characterization of a human beta-Gal-3'-sulfotransferase that acts on both type 1 and type 2 (Gal beta 1-3/1-4GlcNAc-R) oligosaccharides". J Biol Chem. 276 (1): 267–74. doi:10.1074/jbc.M005666200. PMID 11029462.
  6. ^ a b "Entrez Gene: GAL3ST2 galactose-3-O-sulfotransferase 2".

Further reading

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