GBAS (gene)

From Wikipedia, the free encyclopedia
Jump to: navigation, search
NIPSNAP2
Identifiers
Aliases NIPSNAP2, GBAS, glioblastoma amplified sequence, nipsnap homolog 2
External IDs MGI: 1278343 HomoloGene: 1137 GeneCards: NIPSNAP2
Gene location (Human)
Chromosome 7 (human)
Chr. Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for NIPSNAP2
Genomic location for NIPSNAP2
Band 7p11.2 Start 55,951,793 bp[1]
End 56,000,181 bp[1]
RNA expression pattern
PBB GE GBAS 201816 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001483
NM_001202469

NM_008095

RefSeq (protein)

NP_001189398
NP_001474

n/a

Location (UCSC) Chr 7: 55.95 – 56 Mb Chr 5: 129.73 – 129.76 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein NipSnap homolog 2 is a protein that in humans is encoded by the GBAS gene.[5][6][7]

Chromosomal region 7p12, which contains GBAS, is amplified in approximately 40% of glioblastomas, the most common and malignant form of central nervous system tumor.The predicted 286-amino acid protein contains a signal peptide, a transmembrane domain, and 2 tyrosine phosphorylation sites. The GBAS transcript is expressed most abundantly in heart and skeletal muscle. GBAS protein might be involved in vesicular transport.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146729 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029432 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Wang XY, Smith DI, Liu W, James CD (Aug 1998). "GBAS, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR". Genomics. 49 (3): 448–51. doi:10.1006/geno.1998.5239. PMID 9615231. 
  6. ^ Seroussi E, Pan HQ, Kedra D, Roe BA, Dumanski JP (Jul 1998). "Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family". Gene. 212 (1): 13–20. doi:10.1016/S0378-1119(98)00098-5. PMID 9661659. 
  7. ^ a b "Entrez Gene: GBAS glioblastoma amplified sequence". 

Further reading[edit]