GBF1

GBF1
Identifiers
Aliases	GBF1, ARF1GEF, golgi brefeldin A resistant guanine nucleotide exchange factor 1, CMT2GG
External IDs	OMIM: 603698; MGI: 1861607; HomoloGene: 37897; GeneCards: GBF1; OMA:GBF1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	102,382,899 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	46,274,949 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; ventricular zone; ; anterior pituitary; ; sural nerve; ; stromal cell of endometrium; ; ganglionic eminence; ; right lobe of thyroid gland; ; apex of heart; ; mucosa of transverse colon; ; right hemisphere of cerebellum;
	Top expressed in
	neural layer of retina; ; zygote; ; tail of embryo; ; lacrimal gland; ; secondary oocyte; ; genital tubercle; ; muscle of thigh; ; seminiferous tubule; ; molar; ; parotid gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-3,5-bisphosphate binding; protein binding; guanyl-nucleotide exchange factor activity; phosphatidylinositol-3,4,5-trisphosphate binding; lipid binding;
Cellular component	lipid droplet; Golgi membrane; trans-Golgi network; cell leading edge; peroxisome; cytoplasm; endoplasmic reticulum lumen; Golgi stack; mitochondrion; cytosol; Golgi apparatus; membrane; cis-Golgi network; endoplasmic reticulum-Golgi intermediate compartment;
Biological process	Golgi disassembly; protein localization to endoplasmic reticulum tubular network; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; protein transport; Golgi organization; viral process; regulation of mitotic cell cycle; endoplasmic reticulum-Golgi intermediate compartment organization; post-Golgi vesicle-mediated transport; establishment of monopolar cell polarity; protein localization to endoplasmic reticulum exit site; regulation of protein localization to cell surface; endoplasmic reticulum to Golgi vesicle-mediated transport; cell activation involved in immune response; protein localization to Golgi apparatus; neutrophil chemotaxis; reactive oxygen species biosynthetic process; retrograde transport, endosome to Golgi; Golgi to endosome transport; regulation of ARF protein signal transduction; COPI coating of Golgi vesicle; transport; regulation of molecular function;
	Sources:Amigo / QuickGO
Orthologs
	8729
	107338
	ENSG00000107862
	ENSMUSG00000025224
	Q92538
	n/a
NM_001199378; NM_001199379; NM_004193; NM_001377137; NM_001377138;
	NM_001377139; NM_001377140; NM_001377141; NM_001391922; NM_001391923; NM_001391924; NM_001391925; NM_001391926; NM_001391927; NM_001391928; NM_001391929; NM_001391930; NM_001391931
	NM_178930
	NP_001186307; NP_001186308; NP_004184
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the GBF1 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107862 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025224 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mansour SJ, Herbrick JA, Scherer SW, Melancon P (Jan 1999). "Human GBF1 is a ubiquitously expressed gene of the sec7 domain family mapping to 10q24". Genomics. 54 (2): 323–7. doi:10.1006/geno.1998.5563. PMID 9828135.
^ "Entrez Gene: GBF1 golgi-specific brefeldin A resistance factor 1".

References

Further reading