GGPS1

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GGPS1
Protein GGPS1 PDB 2fvi.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGGPS1, GGPPS, GGPPS1, geranylgeranyl diphosphate synthase 1
External IDsOMIM: 606982 MGI: 1341724 HomoloGene: 31267 GeneCards: GGPS1
EC number2.5.1.1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for GGPS1
Genomic location for GGPS1
Band1q42.3Start235,327,350 bp[1]
End235,344,532 bp[1]
RNA expression pattern
PBB GE GGPS1 202321 at fs.png

PBB GE GGPS1 202322 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001037277
NM_001037278
NM_004837
NM_001371477
NM_001371478

RefSeq (protein)

NP_001032354
NP_001032354.1

Location (UCSC)Chr 1: 235.33 – 235.34 MbChr 13: 14.05 – 14.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Geranylgeranyl pyrophosphate synthase is an enzyme that in humans is encoded by the GGPS1 gene.[5][6][7]

Function[edit]

This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[7]

Much like its homolog farnesyl diphosphate synthase, GGPS1 is inhibited by bisphosphonate compounds.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152904 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021302 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ericsson J, Greene JM, Carter KC, Shell BK, Duan DR, Florence C, Edwards PA (September 1998). "Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression". Journal of Lipid Research. 39 (9): 1731–9. PMID 9741684.
  6. ^ Kainou T, Kawamura K, Tanaka K, Matsuda H, Kawamukai M (March 1999). "Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human". Biochimica et Biophysica Acta. 1437 (3): 333–40. doi:10.1016/S1388-1981(99)00028-1. PMID 10101267.
  7. ^ a b "Entrez Gene: GGPS1 geranylgeranyl diphosphate synthase 1".
  8. ^ Wiemer AJ, Wiemer DF, Hohl RJ (December 2011). "Geranylgeranyl diphosphate synthase: an emerging therapeutic target". Clinical Pharmacology and Therapeutics. 90 (6): 804–12. doi:10.1038/clpt.2011.215. PMID 22048229.

Further reading[edit]