Gastric inhibitory polypeptide receptor

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Available structures
PDB Ortholog search: PDBe RCSB
Aliases GIPR, PGQTL2, gastric inhibitory polypeptide receptor
External IDs OMIM: 137241 MGI: 1352753 HomoloGene: 20081 GeneCards: GIPR
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for GIPR
Genomic location for GIPR
Band 19q13.32 Start 45,668,244 bp[1]
End 45,683,724 bp[1]
RNA expression pattern
PBB GE GIPR 208105 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 45.67 – 45.68 Mb Chr 19: 19.16 – 19.17 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

The gastric inhibitory polypeptide receptor (GIP-R) also known as the glucose-dependent insulinotropic polypeptide receptor is a protein that in humans is encoded by the GIPR gene.[5][6] The GIP-R is seven-transmembrane proteins found on beta-cells in the pancreas.[7][8]


Gastric inhibitory polypeptide (GIP), also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. It was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. It is involved in several other facets of the anabolic response.[5]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000010310 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030406 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: gastric inhibitory polypeptide receptor". 
  6. ^ Stoffel M, Fernald AA, Le Beau MM, Bell GI (August 1995). "Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization". Genomics. 28 (3): 607–609. PMID 7490109. doi:10.1006/geno.1995.1203. 
  7. ^ "Gastrointestinal Hormones and Peptides". Retrieved 2007-08-24. 
  8. ^ Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels. 8 (3–4): 179–188. PMID 12529935. doi:10.1080/10606820213687. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.