GPHB5

GPHB5
Identifiers
Aliases	GPHB5, B5, GPB5, ZLUT1, glycoprotein hormone beta 5, glycoprotein hormone subunit beta 5
External IDs	OMIM: 609652; MGI: 2156540; HomoloGene: 18476; GeneCards: GPHB5; OMA:GPHB5 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	63,318,935 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	75,463,555 bp
RNA expression pattern
	Top expressed in
	gonad; ; right hemisphere of cerebellum; ; thigh; ; muscle of thigh; ; prefrontal cortex; ; Brodmann area 9; ; lymph node; ; hypothalamus; ; right frontal lobe; ; nucleus accumbens;
	Top expressed in
	embryo; ; primary oocyte; ; zygote; ; neural tube;
	More reference expression data
	n/a
Gene ontology
Molecular function	hormone activity; thyrotropin-releasing hormone receptor binding; protein heterodimerization activity; protein binding;
Cellular component	extracellular region; extracellular space; cytoplasm;
Biological process	regulation of thyroid hormone mediated signaling pathway; cell-cell signaling; hormone-mediated signaling pathway; cell surface receptor signaling pathway; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	122876
	217674
	ENSG00000179600
	ENSMUSG00000048982
	Q86YW7
	Q812B2
	NM_145171
	NM_175644
	NP_660154
	NP_783575
	Wikidata
View/Edit Human	View/Edit Mouse

Glycoprotein hormone beta-5 is a protein that in humans is encoded by the GPHB5 gene.^[5]

GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002).[supplied by OMIM]^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179600 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048982 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: GPHB5 glycoprotein hormone beta 5".

Z. Gong, W. Wang, K. El Omari, A. A. Lebedev, O. B. Clarke, W. A. Hendrickson, Crystal structure of LGR ligand alpha2/beta5 from Caenorhabditis elegans with implications for the evolution of glycoprotein hormones. Proc Natl Acad Sci U S A 120 (1), e2218630120 (2023). https://www.pnas.org/doi/10.1073/pnas.2218630120#

Okada SL, Ellsworth JL, Durnam DM, et al. (2006). "A glycoprotein hormone expressed in corticotrophs exhibits unique binding properties on thyroid-stimulating hormone receptor". Mol. Endocrinol. 20 (2): 414–25. doi:10.1210/me.2005-0270. PMID 16210345.
Sudo S, Kuwabara Y, Park JI, et al. (2005). "Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5". Endocrinology. 146 (8): 3596–604. doi:10.1210/en.2005-0317. PMID 15890769.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi:10.1038/nature01348. PMID 12508121.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hsu SY, Nakabayashi K, Bhalla A (2003). "Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5". Mol. Endocrinol. 16 (7): 1538–51. doi:10.1210/mend.16.7.0871. PMID 12089349.
Nakabayashi K, Matsumi H, Bhalla A, et al. (2002). "Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor". J. Clin. Invest. 109 (11): 1445–52. doi:10.1172/JCI14340. PMC 150994. PMID 12045258.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179600 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048982 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GPHB5 glycoprotein hormone beta 5".

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References

Further reading