GPM6B

GPM6B
Identifiers
Aliases	GPM6B, M6B, glycoprotein M6B
External IDs	OMIM: 300051; MGI: 107672; HomoloGene: 128189; GeneCards: GPM6B; OMA:GPM6B - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp22.2 Start 13,770,939 bp End 13,938,638 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X F5 Start 165,021,907 bp End 165,171,984 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in dorsal motor nucleus of vagus nerve external globus pallidus inferior ganglion of vagus nerve inferior olivary nucleus subthalamic nucleus Region I of hippocampus proper pars reticulata optic nerve postcentral gyrus pars compacta Top expressed in lobe of cerebellum dorsal striatum olfactory tubercle cerebellar vermis optic nerve globus pallidus nucleus accumbens deep cerebellar nuclei prefrontal cortex lateral septal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular function Cellular component integral component of membrane membrane raft plasma membrane membrane Biological process regulation of focal adhesion assembly protein transport multicellular organism development negative regulation of serotonin uptake cell differentiation negative regulation of protein localization to cell surface regulation of actin cytoskeleton organization extracellular matrix assembly ossification nervous system development positive regulation of bone mineralization neuron projection development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2824 14758 Ensembl ENSG00000046653 ENSMUSG00000031342 UniProt Q13491 P35803 RefSeq (mRNA) NM_001001994 NM_001001995 NM_001001996 NM_005278 NM_001318729 NM_001177955 NM_001177956 NM_001177957 NM_001177958 NM_001177959 NM_001177960 NM_001177961 NM_001177962 NM_023122 RefSeq (protein) NP_001001994 NP_001001995 NP_001001996 NP_001305658 NP_005269 NP_001171426 NP_001171427 NP_001171428 NP_001171429 NP_001171430 NP_001171431 NP_001171432 NP_001171433 NP_075611 Location (UCSC) Chr X: 13.77 – 13.94 Mb Chr X: 165.02 – 165.17 Mb PubMed search
Wikidata
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Neuronal membrane glycoprotein M6-b is a protein that in humans is encoded by the GPM6B gene.

In melanocytic cells, GPM6B gene expression may be regulated by MITF.

Further reading

• Yan Y, Lagenaur C, Narayanan V (1993). "Molecular cloning of M6: identification of a PLP/DM20 gene family". Neuron. 11 (3): 423–31. doi:10.1016/0896-6273(93)90147-J. PMID 8398137. S2CID 46719251.
• Narayanan V, Olinsky S, Dahle E, et al. (1998). "Mutation analysis of the M6b gene in patients with Rett syndrome". Am. J. Med. Genet. 78 (2): 165–8. doi:10.1002/(SICI)1096-8628(19980630)78:2<165::AID-AJMG13>3.0.CO;2-L. PMID 9674909.
• Yoshida M, Shan WS, Colman DR (1999). "Conserved and divergent expression patterns of the proteolipid protein gene family in the amphibian central nervous system". J. Neurosci. Res. 57 (1): 13–22. doi:10.1002/(SICI)1097-4547(19990701)57:1<13::AID-JNR2>3.0.CO;2-E. PMID 10397631. S2CID 28005024.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Werner H, Dimou L, Klugmann M, et al. (2002). "Multiple splice isoforms of proteolipid M6B in neurons and oligodendrocytes". Mol. Cell. Neurosci. 18 (6): 593–605. doi:10.1006/mcne.2001.1044. PMID 11749036. S2CID 24468488.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Henneke M, Wehner LE, Hennies HC, et al. (2005). "Mutation analysis of the M6b gene in patients with Pelizaeus-Merzbacher-like syndrome". Am. J. Med. Genet. A. 128 (2): 156–8. doi:10.1002/ajmg.a.30068. PMID 15214007. S2CID 83895622.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.