Glutathione S-transferase Mu 1

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GSTM1
Protein GSTM1 PDB 1gtu.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1, glutathione S-transferase mu 1
External IDs MGI: 95861 HomoloGene: 121492 GeneCards: GSTM1
RNA expression pattern
PBB GE GSTM1 204418 x at fs.png

PBB GE GSTM1 215333 x at fs.png

PBB GE GSTM1 204550 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000561
NM_146421

NM_008183

RefSeq (protein)

NP_000552
NP_666533

NP_032209.1
NP_032209

Location (UCSC) Chr 1: 109.69 – 109.71 Mb Chr 3: 107.98 – 107.99 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Glutathione S-transferase Mu 1 (gene name GSTM1) is a human Glutathione S-transferase.

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a cytoplasmic glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.[3]

References[edit]

Further reading[edit]