GSTM2

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GSTM2
Protein GSTM2 PDB 1hna.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GSTM2, GST4, GSTM, GSTM2-2, GTHMUS, glutathione S-transferase mu 2 (muscle)
External IDs MGI: 1915562 HomoloGene: 41816 GeneCards: 2946
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001142368
NM_000848

NM_026672

RefSeq (protein)

NP_000839.1
NP_001135840.1

NP_080948.2

Location (UCSC) Chr 1: 109.67 – 109.71 Mb Chr 3: 107.93 – 107.93 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Glutathione S-transferase Mu 2 is an enzyme that in humans is encoded by the GSTM2 gene.[1][2][3]

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.[3]

References[edit]

  1. ^ Vorachek WR, Pearson WR, Rule GS (Jun 1991). "Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus". Proc Natl Acad Sci U S A 88 (10): 4443–7. doi:10.1073/pnas.88.10.4443. PMC 51676. PMID 2034681. 
  2. ^ Campbell E, Takahashi Y, Abramovitz M, Peretz M, Listowsky I (Jul 1990). "A distinct human testis and brain mu-class glutathione S-transferase. Molecular cloning and characterization of a form present even in individuals lacking hepatic type mu isoenzymes". J Biol Chem 265 (16): 9188–93. PMID 2345169. 
  3. ^ a b "Entrez Gene: GSTM2 glutathione S-transferase M2 (muscle)". 

Further reading[edit]