GSTT2

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
GSTT2
Protein GSTT2 PDB 1ljr.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGSTT2, GSTT2B, glutathione S-transferase theta 2 (gene/pseudogene)
External IDsMGI: 106188 HomoloGene: 37358 GeneCards: GSTT2
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for GSTT2
Genomic location for GSTT2
Band22q11.23Start23,980,058 bp[1]
End23,983,915 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000854
NM_001302670

NM_010361

RefSeq (protein)

NP_000845
NP_001289599

NP_034491

Location (UCSC)Chr 22: 23.98 – 23.98 MbChr 10: 75.83 – 75.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutathione S-transferase theta-2 is an enzyme that in humans is encoded by the GSTT2 gene.[5][6][7]

Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries.[7]

References[edit]

  1. ^ a b c ENSG00000277897 GRCh38: Ensembl release 89: ENSG00000099984, ENSG00000277897 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033318 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Tan KL, Webb GC, Baker RT, Board PG (Jul 1995). "Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22". Genomics. 25 (2): 381–7. doi:10.1016/0888-7543(95)80037-M. PMID 7789971.
  6. ^ Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334 (3): 617–23. PMC 1219731. PMID 9729470.
  7. ^ a b "Entrez Gene: GSTT2 glutathione S-transferase theta 2".

Further reading[edit]