GSTT2

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GSTT2
Protein GSTT2 PDB 1ljr.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GSTT2, GSTT2B
External IDs MGI: 106188 HomoloGene: 37358 GeneCards: GSTT2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000854
NM_001302670

NM_010361

RefSeq (protein)

NP_000845.2
NP_000845
NP_001289599

NP_034491.2
NP_034491

Location (UCSC) Chr 22: 23.98 – 23.98 Mb Chr 10: 75.83 – 75.83 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Glutathione S-transferase theta-2 is an enzyme that in humans is encoded by the GSTT2 gene.[3][4][5]

Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Tan KL, Webb GC, Baker RT, Board PG (Jul 1995). "Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22". Genomics. 25 (2): 381–7. doi:10.1016/0888-7543(95)80037-M. PMID 7789971. 
  4. ^ Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334 (3): 617–23. PMC 1219731Freely accessible. PMID 9729470. 
  5. ^ a b "Entrez Gene: GSTT2 glutathione S-transferase theta 2". 

Further reading[edit]