GTF3C5

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GTF3C5
Identifiers
Aliases GTF3C5, TFIIIC63, TFIIICepsilon, TFiiiC2-63, general transcription factor IIIC subunit 5
External IDs MGI: 1917489 HomoloGene: 40806 GeneCards: GTF3C5
RNA expression pattern
PBB GE GTF3C5 217876 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001122823
NM_001286709
NM_012087

NM_001290484
NM_148928

RefSeq (protein)

NP_001116295
NP_001273638
NP_036219

NP_001277413
NP_683730

Location (UCSC) Chr 9: 133.03 – 133.06 Mb Chr 2: 28.57 – 28.58 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

General transcription factor 3C polypeptide 5 is a protein that in humans is encoded by the GTF3C5 gene.[3][4]

Model organisms[edit]

Model organisms have been used in the study of GTF3C5 function. A conditional knockout mouse line, called Gtf3c5tm2a(KOMP)Wtsi[9][10] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[11][12][13]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[7][14] Twenty four tests were carried out on mutant mice and two significant abnormalities were observed.[7] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals.[7]

Interactions[edit]

GTF3C5 has been shown to interact with GTF3C2[3] and GTF3C4.[15]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Hsieh YJ, Wang Z, Kovelman R, Roeder RG (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. PMC 84305Freely accessible. PMID 10373544. 
  4. ^ "Entrez Gene: GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa". 
  5. ^ "Salmonella infection data for Gtf3c5". Wellcome Trust Sanger Institute. 
  6. ^ "Citrobacter infection data for Gtf3c5". Wellcome Trust Sanger Institute. 
  7. ^ a b c d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  8. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  9. ^ "International Knockout Mouse Consortium". 
  10. ^ "Mouse Genome Informatics". 
  11. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. PMC 3572410Freely accessible. PMID 21677750. doi:10.1038/nature10163. 
  12. ^ Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. PMID 21677718. doi:10.1038/474262a. 
  13. ^ Collins FS, Rossant J, Wurst W (2007). "A mouse for all reasons". Cell. 128 (1): 9–13. PMID 17218247. doi:10.1016/j.cell.2006.12.018. 
  14. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. PMC 3218837Freely accessible. PMID 21722353. doi:10.1186/gb-2011-12-6-224. 
  15. ^ Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. PMC 84812Freely accessible. PMID 10523658. doi:10.1128/mcb.19.11.7697. 

Further reading[edit]