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Grancalcin

From Wikipedia, the free encyclopedia
GCA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGCA, GCL, grancalcin
External IDsOMIM: 607030; MGI: 1918521; HomoloGene: 22702; GeneCards: GCA; OMA:GCA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_145523

RefSeq (protein)

NP_663498

Location (UCSC)Chr 2: 162.32 – 162.37 MbChr 2: 62.49 – 62.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Grancalcin is a protein that in humans is encoded by the GCA gene.[5][6][7][8]

This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.[8]

Interactions

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GCA (gene) has been shown to interact with SRI.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115271Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026893Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Boyhan A, Casimir CM, French JK, Teahan CG, Segal AW (Mar 1992). "Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes". J Biol Chem. 267 (5): 2928–33. doi:10.1016/S0021-9258(19)50675-5. PMID 1737748.
  6. ^ Teahan CG, Totty NF, Segal AW (Oct 1992). "Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils". Biochem J. 286. ( Pt 2) (2): 549–54. doi:10.1042/bj2860549. PMC 1132932. PMID 1530588.
  7. ^ a b Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW (Jun 2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro". FEBS Lett. 545 (2–3): 151–4. doi:10.1016/S0014-5793(03)00518-0. PMID 12804766. S2CID 42572647.
  8. ^ a b "Entrez Gene: GCA grancalcin, EF-hand calcium binding protein".

Further reading

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