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GSK3B interacting protein is a protein that in humans is encoded by the GSKIP gene.
[5]
Function
This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene.
Chou HY, Howng SL, Cheng TS, Hsiao YL, Lieu AS, Loh JK, Hwang SL, Lin CC, Hsu CM, Wang C, Lee CI, Lu PJ, Chou CK, Huang CY, Hong YR (2006). "GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta". Biochemistry. 45 (38): 11379–89. doi:10.1021/bi061147r. PMID16981698.
Tang XN, Lo CW, Chuang YC, Chen CT, Sun YC, Hong YR, Yang CN (2011). "Prediction of the binding mode between GSK3β and a peptide derived from GSKIP using molecular dynamics simulation". Biopolymers. 95 (7): 461–71. doi:10.1002/bip.21603. PMID21328310.
