Calderón was born in Santiago, Chile in 1971. Growing up in Chile he studied acting at the Theater School of the University of Chile. Calderón also attended the Dell'Arte International School of Physical Theater in California, and receiving a master's degree in Film Theory at the City University of New York.
Calderón's plays include: B, Clase, Diciembre, Escuela, Gold Rush, Kiss, Mateluna, Neva, Quake, Speech, and Villa.
- Rohter, Larry (2013-03-06). "Guillermo Calderón, Writer and Director of 'Neva'". The New York Times. ISSN 0362-4331. Retrieved 2017-12-20.
- "What's Left for Guillermo Calderón". AMERICAN THEATRE. 2016-10-07. Retrieved 2017-12-20.
- "Guillermo Calderón (CHILE)". AO International. Archived from the original on 2017-12-22. Retrieved 2017-12-20.