H1FOO

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H1FOO
Identifiers
Aliases H1FOO, osH1, H1.8, H1oo, H1 histone family member O, oocyte specific
External IDs MGI: 2176207 HomoloGene: 51377 GeneCards: H1FOO
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308262
NM_153833

NM_138311
NM_001346702

RefSeq (protein)

NP_001295191
NP_722575

NP_612184.1
NP_001333631
NP_612184

Location (UCSC) Chr 3: 129.54 – 129.55 Mb Chr 6: 115.94 – 115.95 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Histone H1oo is a protein that in humans is encoded by the H1FOO gene.[3][4]

Function[edit]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.[4]

It incorporates into sperm chromatin after fertilisation.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (November 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  4. ^ a b "Entrez Gene: H1 histone family". 
  5. ^ Mizusawa Y, Kuji N, Tanaka Y, et al. (March 2010). "Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization". Fertil Steril. 93 (4): 1134–1141. doi:10.1016/j.fertnstert.2008.11.028. PMID 19147139. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.